Autoimmune Hemolytic Anemia (AIHA): Symptoms, Diagnosis and Treatment


Jean Harmon (Editor)

Series: Recent Advances in Hematology Research
BISAC: MED038000

Hemolytic anemia is a clinical condition where red blood cell (RBC) destruction exceeds the ability of the body to supply new ones. In immunohemolytic anemia, the causes of the destruction are antibodies against RBC antigens. These antibodies may be either alloantibodies (isoantibodies), transfused or transferred across the placenta (e.g., in hemolytic anemia of the newborn), or autoantibodies (in AIHA). Once formed, these antibodies bind to the surface of RBCs, marking them for destruction in the blood vessels (intravascular hemolysis) and/or for elimination by phagocytosis by macrophages in the reticulo-endothelial system (extravascular hemolysis). This book presents current research on the symptoms, diagnosis and treatment of AIHA. Chapter One examines oxidative stress in AIHA. Chapter Two discusses AIHA in primary immunodeficiency disorders, while Chapter Three studies AIHA in cancer disorders. Chapter Four reviews AIHA post solid organ transplants. The final chapter reviews the incidence, possible pathophysiology, clinical presentations, management strategies and challenges and outcome after an allogeneic hematopoietic stem cell transplant. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. Oxidative Stress Involvement in Auto-Immune Hemolytic Anemia
Eitan Fibach and Mutaz Dana (Department of Hematology, Hadassah – Hebrew University Medical Center, Jerusalem, Israel)

Chapter 2. Autoimmune Hemolytic Anemia in Primary Immunodeficiency Disorders
Nikita Raje, Mukta Sharma, and Ibrahim Ahmed (Children’s Mercy Hospital, Kansas City, MO, USA, and others)

Chapter 3. Autoimmune Hemolytic Anemia in Cancer Disorders
Shimaa L. Nassif, Ibrahim Ahmed, and Dalia Abdelaziz Mobarek (Department of Pediatric Oncology, National Cancer Institute, University of Cairo, Cairo, Egypt, and others)

Chapter 4. Post Solid Organ Transplant Complication-Auto-Immune Hemolytic Anemia
Mukta Sharma, Nikita Raje, and Ibrahim Ahmed (Children’s Mercy Hospital, Kansas City, MO, USA, and others)

Chapter 5. Post Allogeneic Hematopoietic Stem Cell Transplant Complication Auto-immune Hemolytic Anemia
Ibrahim Ahmed, and Mukta Sharma (Children’s Mercy Hospital, Kansas City, MO, USA, and others)


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