Autoimmune Disorders: Risk Factors, Pathogenesis and Treatments


Series: Immunology and Immune System Disorders
BISAC: MED044000

Autoimmune diseases (ADs) occur when the immune system is mistakenly activated and attacks self antigens present in our body, leading to tissue destruction. Increasing prevalence of ADs is not only a problem for the affected patients but also causes enormous economic burden to the society. Genetic, environmental and epigenetic factors, and interactions between them contribute to the clinical disease outcome. Although most of these diseases are polygenic and multifactorial, and the clinical spectrum differs significantly between the ADs, shared genes and pathogenic pathways attacking specific tissues or organs do exist.

Hence, better understanding of the immunological and pathological basis of these diseases will help to design early diagnostic methods, identify new drug targets, optimize treatments to alleviate sufferings of patients, and develop vaccines and methods to control progression of disease manifestations. This book is organized into seven chapters: Detailed description of Multiple Sclerosis (MS), Inflammatory Bowel Disease (IBD) and Psoriasis (Ps); Antibody mediated disease pathogenesis in Rheumatoid arthritis (RA) and type I diabetes (T1D), antibody glycosylation and its critical role in its effector functions; macrophages in inflammation and its resolution and, the use of nanoparticle-based drug delivery systems for ADs are discussed in detail.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents


Chapter 1. Risk, Pathogenesis and Treatment of Multiple Sclerosis
(Pernilla Stridh, PhD, Ingrid Kockum, PhD, and Ali Manouchehrinia, PhD, Karolinska Neuroimmunology and Multiple Sclerosis Centre, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden, and others)

Chapter 2. The Risk Factor, Pathogenesis and Treatments of Inflammatory Bowel Disease
(Xiaoyan Shen, MD, PhD, Yirui Wang, Haidong Li and Xinyue Cao, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China)

Chapter 3. Psoriasis: Genetic Predisposition, Pathogenesis, Treatment and the Role of Microbiome
(Ia Khmaladze, PhD, Susanne Fabre, PhD, and Kutty Selva Nandakumar, PhD, DSc, Skin Research Institute, Oriflame Cosmetics, Mäster Samuelsgatan, Stockholm, Sweden, and others)

Chapter 4. Pathogenic and Protective Autoantibodies in Arthritis and Diabetes
(Christiane S. Hampe, PhD, Merrill J Rowley, PhD, and Kutty Selva Nandakumar, PhD, DSc Department of Medicine, University of Washington, Seattle, US, and others)

Chapter 5. N-Glycans Modulate IgG Effector Functions and Antibody-Dependent Inflammation
(Kutty Selva Nandakumar PhD, DSc, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China)

Chapter 6. Macrophages in the Activation and Resolution of Inflammation
(Kangxin Li, PhD and Kutty Selva Nandakumar, PhD, DSc, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China)

Chapter 7. Nano-Size Based Drug Delivery Systems for Autoimmune Diseases
(Akhilesh Kumar Shakya, PhD, and Kutty Selva Nandakumar, PhD, DSc, Department of Chemical Engineering, Texas Tech University, Texas, US, and others)



Basic and Pre-clinical researchers, Science students, Medical professionals and students, Biotechnology and Biopharma companies, Patients with autoimmune diseases, and general public interested in scientific and medical research.


Antibodies, Autoimmune Diseases, Genes, Glycosylation, Inflammatory Bowel Disease, Macrophages, Multiple Sclerosis, Nanoparticles, Psoriasis, Rheumatoid Arthritis, Type 1 Diabetes

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