Association of ROBO1 Polymorphism rs6803202 with Developmental Dyslexia in Southern Chinese Children


Authors: Shitao Rao, Yan Nam Lee, Cadmon KP Lim, Venus SF Yeung, Connie SH Ho, Larry Baum, Catherine McBride, and Mary MY Waye
Page Range: 31-38
Published in: Journal of Biochemistry and Molecular Biology in the Post Genomic Era, 3#1 (2013)
ISSN: 2156-5732

Table of Contents


Background: Developmental dyslexia (DD) is the most common learning disability worldwide. A ROBO1 polymorphism, rs6803202, was found to be correlated with the short-term memory of meaningful verbal sequences and was associated with DD. However, the results were not consistent, and most of the studies were only done in Caucasians but not in Chinese, and different genetic background might exist between Caucasians and Chinese. Moreover, DD is a common learning disorder in Hong Kong children, with a prevalence rate up to 12.6%. Thus, it is worthwhile to study the association between rs6803202 and DD in Hong Kong Chinese children.

Methods: DNA was extracted from saliva samples of 107 dyslexic children and 95 ethnicity-matched control subjects. Genotyping of rs6803202 was carried out with real-time PCR using TaqMan probes.

Results: The C allele of rs6803202 was associated with DD after controlling for the effect of gender (adjusted P-value = 0.014, OR = 1.65). Genotypes containing the C allele were also associated with DD (adjusted P-value = 0.013, OR = 2.32).

Conclusions: Association was found between the ROBO1 polymorphism rs6803202 and DD in southern Chinese children. However, the association should be validated by further studies due to the limited sample size of this study.

Keywords: developmental dyslexia (DD), Hong Kong Chinese children, ROBO1 gene, susceptibility gene, case-control association study

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