Are Chronic Degenerative Diseases Part of the Ageing Process? Insights from Comparative Biology

Michael A. Singer
Faculty of Health Sciences, Queen’s University, Ontario, Canada

Series: Aging Issues, Health and Financial Alternatives, Neuroscience Research Progress
BISAC: MED057000


Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Most of the DNA in the human genome does not encode proteins but it is involved in regulatory functions. In addition, the human genome is characterized by an extensive array of structural DNA variants arising from de novo mutations plus accumulated structural variants transmitted through an individual’s lineage. The result is that each person has a unique genome which is expressed as that person’s unique phenotype. Ageing can be understood at both the species and individual level.

Each species has a programmed ageing and mortality pattern, but within those broad species-specific boundaries there is considerable individual variation. At the individual level, ageing reflects the integrated effects of that individual’s unique mix of DNA structural variants, unique experience-specific epigenetic marks and imperfectly repaired genomic and cellular damage. This book examines human chronic degenerative diseases which are not diseases, but rather variations of the ageing process across individuals. (Imprint: Nova Biomedical )



Chapter I - Background (pp. 1-28)

Chapter II - Atherosclerotic Vascular Disease (pp. 29-50)

Chapter III - Hypertension (pp. 51-86)

Chapter IV - Diabetes Mellitus (Type 2) (pp. 87-124)

Chapter V - Dementia (pp. 125-166)

Chapter VI - Conclusion (pp. 167-172)



This book fits into the area of translational research and is written for medical researchers, molecular biologists and physiologists.

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