Arachidonic Acid: Sources, Biosynthesis and Health Effects


Jason M. O’Keefe (Editor)

Series: Biochemistry Research Trends
BISAC: SCI049000

Arachidonic acid (ARA) is one of the two main polyunsaturated fatty acids (PUFAs) in the brain, especially in neuronal cells, and can be a target in the fight against the major public health concern represented by Alzheimer’s disease (AD) and related disorders in high- as well as in low-income countries where elders constitute a growing part of the population.

This compilation includes topics such as the use of arachidonic acid to prevent Alzheimer’s disease; the dietary effects and sources of ARA; the effect of ARA on key oncogenic pathways in prostate cancer; and the effects of adipokines on prostaglandin E2 production by rheumatoid synovial fibroblasts. (Imprint: Nova)

Table of Contents

Table of Contents


Chapter 1 – The Effects of Dietary Arachidonic Acid (20:4n-6) on Growth, Survival and Hypersaline Stress Resistance in Larval Southern Flounder Paralichthys lethostigma (Jordan and Gilbert 1884) (pp. 1-28)
Wade O. Watanabe, Troy C. Rezek, Moti Harel and Pamela J. Seaton (Center for Marine Science, University of North Carolina Wilmington, Wilmington, NC, USA, and others)

Chapter 2 – Dietary Sources and Health Implications of Arachidonic Acid (pp. 29-82)
Susana Vargas Martins, Cristina Mateus Alfaia, Paula Alexandra Lopes and José Mestre Prates (CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, Pólo Universitário do Alto da Ajuda, Lisboa, Portugal)

Chapter 3 – Control of Intracellular Levels of Free Arachidonic Acid: A Target in Therapeutic or Preventive Strategies against Alzheimer‟s Disease? (pp. 83-126)
Mélanie H. Thomas, Sandra Pelleieux, Ahmad Allouche, Julie Colin, Thierry Oster, Catherine Malaplate-Armand and Jean Luc Olivier (URAFPA-BFLA, Université de Lorraine, Nancy, France)
Free Download Available

Chapter 4 – Arachidonic Acid, Cyclooxygenase and Hepatic Inflammation (pp. 127-134)
Sura Wanessa Santos Rocha and Christina Alves Peixoto (Ultrastructure Laboratory, Institute Aggeu Magalhães – FIOCRUZ, Pernambuco, Brazil, and others)

Chapter 5 – Effect of Arachidonic Acid and Its Producing Enzyme Phospholipase A2α on Key Oncogenic Pathways in Prostate Cancer (pp. 135-164)
Sheng Hua, Chanlu Xie, Mu Yao and Qihan Dong (Discipline of Endocrinology and Central Clinical School and Bosch Institute, Royal Prince Alfred Hospital, The University of Sydney, Sydney, Australia, 2School of Science and Health, The University of Western Sydney, Sydney, Australia)

Chapter 6 – Effects of Adipokines on Prostaglandin E2 Production by Rheumatoid Synovial Fibroblasts (pp. 165-184)
Natsuko Kusunoki, Fumiaki Kojima and Shinichi Kawai (Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, and others)


Publish with Nova Science Publishers

We publish over 800 titles annually by leading researchers from around the world. Submit a Book Proposal Now!