Antiphospholipid Antibodies (APLA): Types and Functions in Health and Disease


Luke E. Ward (Editor)

Series: Immunology and Immune System Disorders
BISAC: MED044000

The opening chapter of Antiphospholipid Antibodies (APLA): Types and Functions in Health and Disease is focused on the modern immunoassays for the determination of aPL in biological fluids. The principles of these methods will be described and the possibility of their applications for aPL analysis will be mentioned. Next, the authors examine antiphospholipid syndrome (APS), a clinical disorder characterized by thrombosis and/or pregnancy morbidity in the persistence of antiphospholipid antibodies (aPL) that are pathogenic and have pro-coagulant activities. Two different strategies on the assessments of the aPL testings are indicated: quantitative assessments of the thrombotic risks using aPL profiles and new combination of aPL tests for screening APS diagnosis. This book goes on to discuss how in 2003, as a parallel to the seronegative rheumatoid arthritis and the seronegative lupus, G.R. Hughes and M.A. Khamashta introduced the term seronegative antiphospholipid syndrome (SN-APS). The diagnosis of SN-APS has been subjected to multiple discussions, disputes and investigations. The review presented in this collection summarizes the contemporary knowledge on SN-APS and its diagnosis and treatment and shows the authors’ experience in this field. In closing, the authors describe the current knowledge on the mechanisms of antiphospholipid antibodies -associated renal damage, the main clinical manifestations, diagnostic and therapeutic considerations in APS in renal patients and our experience in this group.

Table of Contents

Table of Contents


Chapter 1. Profiling of Antiphospholipid Antibodies: The Modern Methods for Their Determination
(Lenka Fialová, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic)

Chapter 2. How Should We Test and Assess Antiphospholipid Antibodies?
(Kenji Oku, MD, PhD, Department of Rheumatology, Endocrinology and Nephrology,
Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan)

Chapter 3. Seronegative Antiphospholipid Syndrome
(Marta Baleva, MD, PhD, and Milena Nikolova –Vlahova, MD, PhD, Department of Clinical Immunology, University Hospital “Alexandrovska”, Sofia, Bulgaria, and others)

Chapter 4. Antiphospholipid Antibodies in Renal Diseases
(Milena Nikolova-Vlahova, Marta Petrova Baleva, Petar Krasimirov Nikolov, Medical University, Sofia, Bulgaria)

Chapter 5. Bibliography

Chapter 6. Related Nova Publication


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