Antimalarial Drugs: Age of the Artemisinins


Qigui Li and Peter J. Weina
Walter Reed Army Institute of Research, Silver Spring, MD, USA

Series: Pharmacology – Research, Safety Testing and Regulation, Tropical Diseases – Etiology, Pathogenesis and Treatments
BISAC: MED071000

Antimalarial drugs are medicines that prevent or treat malaria, a disease which takes a great toll on human health and well-being, particularly in tropical regions including Africa south of the Sahara, South and Southeast Asia, Oceania, and parts of the Americas. In recent years, strains of Plasmodium have become increasingly resistant to more antimalarial drugs and researchers have stepped up efforts to revise antimalarial drug policies and develop new antimalarial strategies. Resistance has arisen to all classes of antimalarials (chloroquine, amodiaquine, mefloquine and sulfadoxine-pyrimethamine) except, as yet, definitively to the artemisinin derivatives. In order to prevent widespread resistance, the concept of antimalarial combination therapy (CT) has been employed and a global resistance surveillance system (World Antimalarial Resistance Networks) has been established. This book explores the use of these drugs in current health care. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents

Preface pp.vii-viii

Abstract pp.1-2

Chapter 1. Current Status and Policies of Antimalarial Drugs pp.3-60

Chapter 2. Antimalarial Drug Cost and Cost-Effectiveness pp.61-110

Chapter 3. Efficacy and Treatment of Antimalarial Drugspp.111-194

Chapter 4. Antimalarial Drugs in Chemoprophylaxis pp.195-242

Chapter 5. Influences on Antimalarial Drug Efficacy pp.243-328

Chapter 6. Toxicity of Antimalarial Drugs pp.329-402

Chapter 7. Antimalarial Drug Toxicity pp.403-464

Chapter 8. Antimalarial Drugs Withdrawn and in the Pipelinepp.465-554

Appendix I pp.555-562

References pp.563-618

Index pp.619-643

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