Antimalarial Drug Research and Development

Antoine C. Banet (Editor)
Philippe E. Brasier (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED058170



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Malaria-like febrile illnesses have been described since Hippocrates as fevers that were periodic and associated with marshes and swamps. The word “malaria” comes from the Italian “mal’ aria” for “bad airs”. Malaria is transmitted to humans via the bite of the infected female mosquito of the anopheles species. Malaria can exist in a mild form that is most commonly associated with flu-like symptoms; fever, vomiting and general malaise. Most disease cases are found in the poorest countries; tropical Africa, Latin America, Southern Asia and Oceania.

More concern is being given now to malaria even in countries where there is a low risk of infection due to the phenomena of global warming which is significantly increasing. In this book, the authors present current research in the study of antimalarial drug research and developments. Topics discussed in this compilation include the antimalarial atovaquone prodrugs based on enzyme models with molecular orbital calculations approach; new quinoline-based multiple ligands in antimalarial drug development; new molecular scaffolds as potential therapeutic agents to combat antimalarial resistance; and PfCRT mediates sensitivity of chloroquine-resistant P. Falciparum to diamidines. (Imprint: Nova Biomedical )


Antimalarial Atovaquone Prodrugs Based on Enzyme Models - Molecular Orbital Calculations Approach
(Rafik Karaman, Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, Jerusalem, Palestine, and others)

New Quinoline-Based Multiple Ligands in Antimalarial Drug Development
(Vladimir V. Kouznetsov, Laboratorio de Química Orgánica y Biomolecular, Escuela de Química, Universidad Industrial de Santander, Bucaramanga, Colombia)

New Molecular Scaffolds as Potential Therapeutic Agents to Combat Antimalarial Resistance
(Margaret Cupit, Taotao Ling, Fatima Rivas, Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA)

PfCRT Mediates Sensitivity of Chloroquine-Resistant P. falciparum to Diamidines
(J. Enrique Salcedo-Sora, Archana Kaniti, Chinyere Emma Okpara, Paul A. Stocks, Giancarlo A. Biagini, Paul M. O’Neill, Stephen A. Ward, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, and others)


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