Antigenicity and Immunogenicity of the Envelope Glycoprotein (gpG) of Viral Haemorrhagic Septicaemia Rhabdovirus (VHSV)


A. Falco, M. Ortega-Villaizan, J.M. Coll and A. Estepa
Miguel Hernández University, Elche, Spain, and others

Series: Immunology and Immune System Disorders
BISAC: MED044000

Among the 5 structural proteins of the salmonid rhabdovirus viral haemorrhagic septicaemia virus (VHSV), the glycoprotein G (gpG) is a unique immunogenic (immune response) and antigenic (antibody) inducer. While recombinant gpG proteins had limited success as vaccines, their corresponding gpG DNA have been highly protective in different fish species (most probably because that is the best way to maintain their epitopes, disulphide bonds and glycosilation). (Imprint: Novinka)

Table of Contents

Table of Contents


Importance of Rhabdoviral Diseases in Farmed Fish

Viral Haemorrhagic Septicemia Virus (VHSV)

The Structure-Function Relationships in the Glycoprotein G of VHSV (gpGVHSV)

The Importance of the gpGVHSV in Vaccination against VHSV

Early gpGVHSV Immunogenicity: Activation of the Interferon (IFN) System

Long-Term gpG Immunogenicity: Induction of T Cellular Responses

Long-Term gpGVHSV Antigenicity: Antibody Responses



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