Anticancer Therapies: Advances in Research and Applications

George Moyer (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: HEA039030

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In the first chapter, I-Ling Hung, Yu-Chiang Hung, and Wen-Long Hu examine the synergistic processes of herbal ingredients in order to help researchers discover new phytomedicines. Next, in the second chapter, Muhammad Imran Qadir gives a synopsis of the discussion regarding the cure of developed prostate cancer by using androgen deprivation therapy. Ddiethylstilbestrol was previously used to achieve androgen deprivation, but luteinizing hormone-releasing hormone (LHRH) replaced it and a slew of detrimental effects ensued. Unconventional therapy has been implemented to decrease the adverseness of treatment. The third chapter, also by Muhammad Imran Qadir, elaborates on the risk factors of breast cancer, such as early menarche and late menopause. In the fourth chapter, he discusses the impact of synthetic peptides in liver cancer management.

Continuing, he uses the fifth chapter to discuss the use of a hepatic sgRNA or single guide RNA delivery system to target a large proportion of gene sets to induce the hepatocellular carcinoma (HCC) and intra-hepatic cholangio-carcinoma (ICC), concluding that the CRISPR/Cas9 gene targeting could be used to manage HCC, the predominant cause of cancer-related deaths. In the sixth chapter written by Muhammad Imran Qadir, the decrease in potential risk of cancer via blockers of IGF-1R in prostate and colon carcinomas and use of anti-IGF therapy in grouping of cytotoxic drugs is examined. In the seventh chapter, Sara Tabassum joins Muhammad Imran Qadir in exploring the potential for telomere, or its enzyme, to be used as a target drug or in the screening process for treatment of cancer. Muhammad Imran Qadir goes on to examine how CK-19 helps to differentiate papillary thyroid carcinomas from other malignant and benign forms in the eighth chapter. In the ninth chapter, he analyzes the distinctive biological properties of Nanoparticles due to small size and a large surface area to volume ratio. In the tenth chapter, Muhammad Imran Qadir studies the part BRCA mutations play in breast cancer development. Simona Martinotti, Mauro Partrone, Giorgio Calabrese, and Elia Ranzato review current research that suggests potential uses of ascorbate in cancer treatment in the eleventh chapter. Lastly, the twelfth chapter provided by Muhammad Imran Qadir presents a study that offers a new modernization for Caspase substrates. (Imprint: Nova Biomedical)

Preface

Chapter 1. Complementary Therapies with Traditional Chinese Medicine for Gynecological Cancers and Breast Cancer: Evidence from Experimental Research to Clinical Study
I-Ling Hung, Yu-Chiang Hung, and Wen-Long Hu (Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and School of Traditional Chinese Medicine, Chang Gung University College of Medicine, Kaohsiung, Taiwan, and others)

Chapter 2. Androgen Deprivation Therapy for the Treatment of Prostate Cancer
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 3. Early Menarche, Late Menopause and Advancing Age: Risk Factors for Breast Cancer
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 4. The Significance of Synthetic Peptides in Liver Cancer Management
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 5. CRISPR/Cas9 System: A Double Edged Sword in Cancer
Muhammad Imran Qadir and Warda Ramzan (Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 6. The Role of an Insulin-like Growth Factor (IGF) in Carcinogenesis
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 7. Telomerase Activity and Its Effect on Cancer Cells
Muhammad Imran Qadir and Sara Tabassum (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 8. Cytokeratin 19: A Forecasting Immunohistomarker for the Detection of Thyroid Carcinomas
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 9. The Importance of Nanotechnology in Diagnosis of Liver Cancer
Muhammad Imran Qadir and Ayesha Aslam (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 10. The Role of BRCA1 and BRCA2 Gene Mutation in Breast Cancer Progression
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

Chapter 11. Ascorbate and Cancer Therapy: Possible Support from Dietary Habits
Simona Martinotti, Mauro Partrone, Giorgio Calabrese, and Elia Ranzato (University of Piemonte Orientale, DiSIT- Dipartimento di Scienze e Innovazione Tecnologica, Alessandria, Italy, and others)

Chapter 12. The Role of Caspase Substrates in Apoptosis
Muhammad Imran Qadir (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan)

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