Anti-Müllerian Hormone: Biology, Role in Ovarian Function and Clinical Significance

David B. Seifer, MD (Editor)

Reshef Tal, MD, PhD (Editor)
Division Chief of Reproductive Endocrinology and Infertility, Oregon Health Science University, Portland, OR, USA

Series: Obstetrics and Gynecology Advances
BISAC: MED033000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This is the first book published that discusses state of the art research regarding AMH in human reproduction and medicine. This unique and vital protein impacts a variety of fundamental processes within the ovaries and testes. Since its discovery in 1947, every medical student has learned about the role AMH plays in embryonic sexual differentiation. However, the last fifteen years have witnessed AMH emerge from the bench to the bedside, from a scientific curiosity to a useful diagnostic tool with clinical utility and therapeutic applications. In female reproduction, AMH has undergone a virtual renaissance after it was discovered in the human ovarian follicle and later to reflect ovarian reserve.

Since that time, much has been learned regarding the role of AMH in female reproductive aging and a number of other gynecological conditions. This is reflected by a number of peer-reviewed publications on AMH in human adult females, which has increased exponentially over the past three decades. It is only in the last decade that AMH has become an important marker of ovarian response, guiding clinical decision making in assisted reproductive technology (ART) as well as a useful aid in the diagnosis of polycystic ovarian syndrome (PCOS). In male reproduction, AMH has become a diagnostic tool in the complex evaluation of infants with intersex conditions, including ambiguous genitalia and cryptorchidism. The chapters of this book bring together experienced investigators with a variety of research interests in different aspects of AMH.

Each contributor has conducted clinical, translational and/or basic research in the field of AMH. Each has an appreciation of what is known and an aspiration for solving what remains to be discovered. A better understanding of AMH pathophysiology may lead to the development of pharmacological treatments using AMH agonists and/or antagonists for a host of reproductive challenges. These include: the possible retardation of ovarian aging and menopause; a chemoprotectant for fertility preservation prior to chemotherapy; a tool to better control ovarian response to ART and/or to mitigate the deleterious effects of polycystic ovary syndrome; and a treatment for endometriosis, adenomyosis and/or endometrial and ovarian cancers. This book enables the reader to review the past, understand the present and consider the future of this multifaceted protein in the fields of reproductive medicine and gynecology.
(Imprint: Nova Biomedical)

Dedication

Foreword

Introduction

Chapter 1 pp. 1-12.: The Relevance of AMH to Human Reproductive Biology and Medicine
(David B. Seifer, and Reshef Tal, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, and others)

Chapter 2 pp. 13-32.: Basic Biology of AMH: Structure, Signaling Pathways, and Role in Normal Folliculogenesis
(Jenny A. Visser, Dept. of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands)

Chapter 3 pp. 33-46.: Studies on Anti-Müllerian Hormone Production, Action, and Regulation in the Primate Ovary: Insight into Human Folliculogenesis
(Jing Xu, Mary B. Zelinski, Richard L. Stouffer, Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA, and others)

Chapter 4 pp. 47-60.: Options for Choosing Different AMH Assays
(Richard Fleming, Scientific Director, Glasgow Centre for Reproductive Medicine, Glasgow, UK, and others)

Chapter 5 pp. 61-72.: The Value of Normative Data on AMH in Women
(Joop S.E. Laven, Head of Div. of Reproductive Medicine, Dept. OBGYN, Erasmus MC, Rotterdam, The Netherlands)

Chapter 6 pp. 73-82.: Anti-Müllerian Hormone and the Prediction of Age at Natural Menopause
(M. Depmann, F.J.M. Broekmans, Division Woman and Baby, Voortplantingsgeneeskunde, University Medical Center Utrecht, Netherlands)

Chapter 7 pp. 83-102.: Using AMH for Determining a Stratified Gonadotropin Dosing Regimen for IVF/ICSI and Optimizing Outcomes
(Joan-Carles Arce, Bjarke M. Klein, Lars Erichsen, Reproductive Health, Global Clinical R&D, Ferring Pharmaceuticals, Copenhagen, Denmark, and others)
Free Download Available

Chapter 8 pp. 103-116.: How AMH assists Counselling for Fertility Preservation prior to Treatment for Cancer
(CE Dunlop and RA Anderson, MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, Scotland)

Chapter 9 pp. 117-130.: AMH in Diagnosis and Treatment of Gonadal Tumors
(Geralyn Lambert-Messerlian, Rodolfo Rey, Director, Women and Infants Hospital, Professor
Alpert Medical School at Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island, USA, and others)

Chapter 10 pp. 131-146.: Assessment of Ovarian Reserve before and after Gynecologic Surgery
(Akira Iwase, Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan)

Chapter 11 pp. 147-164.: The Utility of AMH in the Diagnosis and Treatment of PCOS
(A.Dumont, G. Robin, S. Catteau-Jonard, D. Dewailly, Service de Gynécologie Endocrinienne et de Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU de Lille, France)

Chapter 12 pp. 165-174.: The Role of AMH in Endometriosis
(Patrizia Carrarelli, Lucia Funghi, Alessandra Gatti, Felice Arcuri and Felice Petraglia, Università degli Studi di Siena, Department of Molecular & Developmental Medicine, Siena, Italy)

Chapter 13 pp. 175-196.: Applications of AMH in Pediatric Endocrinology
(Analía V. Freire, Romina P. Grinspon and Rodolfo A. Rey, Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), CONICET – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Gallo – Buenos Aires - Argentina)

Chapter 14 pp. 197-208.: Anti-Müllerian Hormone and Premature Ovarian Insufficiency
(Laetitia Jacquesson, Anne Bachelot, Philippe Touraine, Department of Endocrinology and Reproductive Medicine Pitieì-SalpêtrieÌre Hospital, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France, and others)

Chapter 15 pp. 209-226.: A Critical Evaluation of whether Circulating Anti-Müllerian Hormone is a Hormone in Adults, with Special Reference to its Putative Roles in Men
(Ian S. McLennan, Yih Harng Chong, Yui Kawagishi, Michael W. Pankhurst, Department of Anatomy, Otago School of Medical Sciences, Brain Health Research Centre, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand)
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Chapter 16 pp. 227-240.: Summary of Current State of AMH Utilisation in Clinical Reproductive Medicine
(Scott M. Nelson, Muirhead Professor of Obstetrics and Gynaecology, School of Medicine, University of Glasgow, Denmark)

Chapter 17 pp. 241-256.: Racial/Ethnic Differences in AMH and Potential Underlying Mechanisms
(Reshef Tal, and David B. Seifer, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA, and others)

Chapter 18 pp. 257-268.: Influence of Combined Contraceptives on Serum AMH
(Christopher E. Gibson, Clarisa R. Gracia, Division of Pediatric Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Pennsylvania, USA, and others)

Chapter 19 pp. 269-280.: Anti-Mullerian Hormone and Obesity
(Vicky Moy and Erkan Buyuk, Department of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA)

Chapter 20 pp. 281-290.: Association between Vitamin D and Anti-Mullerian Hormone
(Mohamad Irani, Zaher Merhi, Weill Cornell Medical Center, The Ronal O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, NY, USA, and others)

Chapter 21 pp. 291-308.: Anti-Müllerian Hormone (AMH) and FMR1 Genotype
(Shohat-Tal, A., Gleicher, N., Center for Human Reproduction, New York, N.Y, USA)

Chapter 22 pp. 309-326.: AMH Screening of Ovarian Reserve in the General Population: A Risk-Benefit Analysis
(Kelton Tremellen, Neerja Kamal, Consultant Gynaecologist and Reproductive Endocrinologist
Professor of Reproductive Medicine, Flinders University, Bedford Park, South Australia)

Chapter 23 pp. 327-334.: Future Research and Potential Therapeutic Applications: Agonists and Antagonists
(Elodie Adda-Herzog, Nathalie di Clemente, Renato Fanchin, Center of Reproductive Medicine and Biology, Obstetrics and gynecology department, Hôpital Antoine Béclère (AP-HP), Paris-Sud University, France, and others)

Index

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