Androgen Receptor: Structural Biology, Genetics and Molecular Defects

Silvia Socorro, PhD (Editor)
Universidade da Beira Interior, Faculdade de Ciências da Saúde, Covilhã, Portugal

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The androgen receptor (AR) mediates a wide range of physiological actions of androgens in cells and tissues. Contributions to this volume cover distinct topics of AR signalling, extending from the structural aspects of AR to its role in androgen-associated diseases and potential clinical applications. Some key issues covered include an overview of structural aspects of AR genes and proteins in mammalian and non-mammalian vertebrate species and a description of the identified AR splice variants in pathological and non-pathological conditions.

The structural and functional analysis of coding and untranslated regions of AR are discussed in the context of diseases such as androgen insensitivity syndrome, spinal and bulbar muscular atrophy, polycystic ovarian syndrome and breast, ovary and prostate cancers. The role of AR regulated genes implicated in prostate cancer progression is also explored. This book is a comprehensive conceptual review of the recent findings on AR genes and protein structure, molecular variants, ligands, target genes and signalling mechanisms. Graduate students, scientists and professionals can use it as both a study text and a reference for research purposes. (Imprint: Nova Biomedical )

Preface

Chapter 1. Androgen Receptors in Non-Mammalian Vertebrates: Structure and Function
(P. Pinto, M. D. Estêvão and S. Socorro, CCMAR - Centre of Marine Sciences, Universidade do Algarve, Faro, Portugal and others)

Chapter 2. Naturally Occurring Androgen Receptor Splice Variants: Impact on Androgen Signaling Pathways
(J. E. Cavaco, S. Laurentino, S. Correia, P. Pinto and S. Socorro, CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal and others)

Chapter 3. Structural and Functional Analysis of the Androgen Receptor in Disease
(N. Gallastegui and E. Estébanez-Perpiñá, Institute of Biomedicine of the University of Barcelona (IBUB), Spain)

Chapter 4. Androgen Receptor Signaling in Prostate Cancer: Genetic and Molecular Aspects
(L. G. A. Chuffa, J. P. A. Amorim and B. A. Fioruci-Fontanelli, Department of Anatomy - IBB/UNESP – Univ Estadual Paulista, SP, Brazil and others)

Chapter 5. The Role of Androgen Receptor-Regulated Genes in Prostate Cancer Progression
(J. Lu and D. J. Tindall, Departments of Urology Research/Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA and others)

Chapter 6. Computational Prediction of Regulatory Regions of the Androgen Receptor Messenger RNA
(J. Spence, Omnitron Biosciences, San Diego, California, USA)

Chapter 7. Androgens and the Ovary
(R. Sá and M. Sousa, Department of Microscopy, Laboratory of Cell Biology, Building-1, Floor-2, Room 03, Unit for Multidisciplinary Investigation in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal and others)

Index

Audience: Graduate students, scientists and professionals in the field of Endocrinology and/or Biology of Reproduction.

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