Anatomy and Physiology of Proteins: Caldesmon


Edward A. Czurylo and Natalia Kulikova
Nencki Institute of Experimental Biology, Warsaw, Poland

BISAC: SCI056000

Caldesmon is one of the most abundant proteins detected in smooth muscle and in a number of non-muscle cells. It binds actin, myosin, tropomyosin and calmodulin and is believed to play in smooth muscle a regulatory role similar to that of troponin in striated muscle. Two closely-related isoforms of caldesmon being the products of an alternative splicing of a single gene, have been identified. The high molecular weight (H-CaD) isoform is expressed predominantly in smooth muscle, whereas the low molecular weight (L-CaD) isoform is found in non-muscle tissues and cells. This book examines the anatomy and physiology of caldesmon proteins. (Imprint: Novinka )


Table of Contents

Table of Contents



“Anatomy” of Caldesmon

1. Preparation and purification of caldesmon

2. Structure of caldesmon molecule

“Physiology” of Caldesmon

3. Interaction of caldesmon with other proteins

4. The role of caldesmon in thin filaments

5. Cell and tissue distribution of caldesmon



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