Amyloid Precursor Protein: Structure, Functions and Interactions


Richard Ducharme (Editor)

Series: Biochemistry and Molecular Biology in the Post Genomic Era,
BISAC: SCI049000

The role of epigenetic modifications in gene-gene and/or gene-environment interactions in rare diseases is a key issue in molecular physiology and medicine as certain principles may be applied in other common and complex disorders. As such, Amyloid Precursor Protein: Structure, Functions and Interactions first investigates the normal functions of amyloid precursor protein (APP). Next, recent evidence derived from cellular and animal models is presented, strongly suggesting that the APP intracellular domain and its interacting proteins could play an unprecedented role in the physiological functions of APP, and that its deregulation has a profound impact on the initiation of Alzheimer’s disease. In closing, the authors review the expression of APP in cases of traumatic brain injury with different chronological evolutions. APP accumulates in all cases of axonal damage, whatever its cause may be.

Table of Contents

Table of Contents


Chapter 1. Impact of the Human β-Amyloid Precursor Protein (APP) on Human Disease and Antisense Therapy
(Khue Vu Nguyen, PhD, Department of Medicine, Biochemical Genetics and Metabolism, Mitochondrial and Metabolic Disease Center, School of Medicine, University of California, San Diego, CA, US, and others)

Chapter 2. The APP Intracellular Domain (AICD) Interactome: Connecting APP Physiological Functions and Alzheimer’s Disease Pathologic Features
(Pamela J. Urrutia, PhD, and Daniel A. Bórquez, PhD, Laboratory of Cell Signaling and Bioinformatics, Center for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile)

Chapter 3. Amyloid Precursor Protein and Diffuse Axonal Injury after Severe Head Trauma: A Forensic Point of View
(María Ángeles Romero Tirado, MD, PhD, Rosalía Gallego Gómez. MD, PhD, Marta Varela Gómez, MD, and Lucía García-Caballero, DDS, PhD, Department of Forensic Pathology, Institute of Legal Medicine of Galicia, Spain, and others)


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