Aminoglycosides: Pharmacology, Clinical Uses and Health Effects

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Ruthie Alves (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Aminoglycosides are a commonly used class of antibiotic worldwide, with examples including gentamicin, tobramycin and amikacin. Their low cost, together with their effectiveness against Gram-negative organisms, including Pseudomonas aeruginosa, makes them a valuable tool in treating infections. In addition, aminoglycosides have demonstrated lower rates of resistance in both community and healthcare settings when compared with many other antimicrobials and exhibit synergistic activity with beta-lactams against certain Gram-positive organisms, such as streptococcus and enterococcus. Unfortunately, aminoglycosides exhibit a narrow therapeutic index, which can result in toxicity if care is not taken with their use. This book reviews the pharmacology, clinical uses and health effects of aminoglycosides. (Imprint: Nova Biomedical)

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Table of Contents

Preface

Chapter 1. Amphiphilic Analogues of Aminoglycosides as Antitubercular and Antimicrobial Agents
Dylan C. Farr, I. Darren Grice and Todd A. Houston (Institute for Glycomics, Gold Coast Campus, Griffith University, QLD, Australia)

Chapter 2. Aminoglycoside use in Patients with Chronic Kidney Disease
Melissa Nataatmadja, Yeoungjee Cho, Jess Lloyd, and David W. Johnson (Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia, and others)

Chapter 3. Partial or Complete Vestibular Recovery is related to the Presence of mitDNA Specific Polymorphisms in Aminoglycoside Antibiotic Treated Female Patients
Beatriz Aguilar Maldonado, María Cecilia Esteinou Madrid, Laura Ongay Larios, and Graciela Meza (División de Neurociencias and Unidad de Biología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, México, and others)

Chapter 4. Commentary – Gentamicin-Induced Nephrotoxicity: Sesame Oil as a Potential Protective Agent
Srinivasan Periasamy, Chuan-Teng Liu and Ming-Yie Liu (Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan)

Index

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