Alpha-Synuclein: Functional Mechanisms, Structure and Role in Parkinson’s Disease

Mark Polizzi (Editor)
Howard C. Kanowitz (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000



Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Alpha-synuclein is a synuclein protein of unknown function primarily found in neural tissue, making up as much as 1% of all proteins in the cytosol. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum. In this book, the authors discuss the functional mechanisms, structure and role in Parkinson’s disease of alpha-synuclein.

Topics include á-synuclein accumulation in Parkinson’s disease and multiple system atrophy; á-synuclein metabolism and aggregation in the pathogenesis of Parkinson’s disease; and the potential role of á-synuclein dysregulation in Parkinson’s disease pathology. (Imprint: Nova Biomedical )


á-Synuclein Accumulation in Parkinson’s Disease and Multiple System Atrophy
(Ikuru Yazawa, Yasuyo Suzuki, Laboratory of Research Resources, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan)

á-Synuclein Metabolism and Aggregation in the Pathogenesis of Parkinson’s Disease
(Yoshihisa Watanabe, Atsushi Tsujimura, Katsutoshi Taguchi, Masaki Tanaka, Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan)
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Potential Contribution of á-Synuclein Dysregulation to Parkinson’s Disease Pathology
(Jose L. Porras, Ruth G. Perez, Department of Biomedical Sciences, Center for Excellence in Neurosciences, Texas Tech University Health Sciences Center at El Paso, Paul L. Foster School of Medicine, El Paso, TX, USA)
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