Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology

Vittorio Unfer
A.G.UN.CO Obstetrics and Gynecology Center, Rome, Italy

Series: Therapeutic Approaches in Common Obstetrics and Gynecological Disorders
BISAC: MED033000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology focuses on the rationale of Alpha-Lipoic Acid (ALA) use in the field of maternal-fetal medicine and its clinical applications.

So far, the use of ALA is promising in several conditions which involve inflammation, oxidation, and tissue damage in their pathophysiology. Indeed, several studies provide a reliable amount of data related to the therapeutic use of ALA in different disorders such as cancer, neurodegenerative diseases, diabetes, tissue regeneration, ischemia–reperfusion injury, and aging.

According to the multiple actions of ALA and its safe profile, this book provides valuable updates regarding the positive role of ALA supplementation from implantation to parturition, and includes research and information from newer published studies in this field.
The rationale of ALA use in obstetrics, the current preclinical and clinical evidences on the administration of ALA to maintain the physiological state of pregnancy and treat pathological conditions such as threatened miscarriage, and preterm delivery represent the core of this composition.

In addition, to contain the core science of ALA in pregnancy, this book is designed to serve both as a valuable clinical reference for the obstetricians and as a starting point for the development of new experimental and clinical studies on the use of ALA in pregnancy.


Chapter 1. Alpha Lipoic Acid in Obstetrics: Rationale for Use in Clinical Practice
(Marco Tilotta, Sara De Grazia and Vittorio Unfer, Medical Affairs Department Lo.Li. Pharma SrL, Rome, Italy, and A.G.UN.CO Obstetrics and Gynecology Center, Rome, Italy)

Chapter 2. The Effects of Lipoic Acid on Wound Healing in a Uterine Injury Rat Model: Clinical Perspectives in Obstetric Surgery
(Asli Goker and Naci Kemal Kuscu, Obstetrics and Gynecology, Celal Bayar University, Manisa, Turkey)

Chapter 3. The Use of Lipoic Acid in Supporting Pregnancy Physiology and Pregnancy Length: Preclinical Evaluation
(Serap Cilaker Micili and Bekir Ugur Ergür, Department of Histology and Embryology, Dokuz Eylül University, Izmir, Turkey)

Chapter 4. Lipoic Acid Effects upon Human Fetal Membrane Weakening
(Anudeepa Sharma, Robert M. Moore, John J. Moore and Deepak Kumar, Department of Pediatrics and Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH, US)

Chapter 5. Clinical Use of Oral Lipoic Acid in Pregnancy
(Giusi Porcaro, Women’s Health Center, Azienda USL Umbria 2, Orvieto, Italy)

Chapter 6. Clinical Use of Vaginal Lipoic Acid in Pregnancy
(Lucrezia Pignatti and Fabio Facchinetti, Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy)

Chapter 7. Safe Use of Lipoic Acid in Pregnancy
(Antonio Simone Laganà, Department of Obstetrics and Gynecology “Filippo Del Ponte” Hospital University of Insubria, Varese, Italy)

Chapter 8. The Potential Role of Lipoic Acid in Assisted Reproductive Technologies
(Kostantinos Ravanos and Nikos Prapas, IAKENTRO Fertility Clinic, Salonicco, Greece)


Keywords: Lipoic acid, pregnancy, inflammation, immunomodulation, miscarriage, preterm delivery

Audience: Gynecologist, Obstetricians

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