Table of Contents
Table of Contents
Preface
Foreword
Section 1: Alpha-fetoprotein History & Normal and Pathological Development
Chapter 1. The History of Alpha-fetoprotein Discovery
Vladimir Jurišić, Dina Nikulina (University of Kragujevac, Faculty of Medical Sciences, Svetozara Marković, Kragujevac, Serbia, and others)
Chapter 2. Alpha-fetoprotein in Development, After Liver Injury, During Chemical Hepatocarcinogenesis and in Liver Cancer: How the Study of Alpha-fetoprotein Led to the Concept of Cancer Stem Cells
Stewart Sell (Senior Research Physician, Wadsworth Laboratory, New York State Dept. of Health. Wadsworth Center, Empire State Plaza, Albany, NY, USA)
Chapter 3. The Role of Alpha-fetoprotein in Human Hepatocellular Carcinoma
Wenbo Meng, Bing Bai, Yan Li, Zhongtian Bai, Ping Yue, Kexiang Zhu, Wence Zhou, Xun Li (Special Minimally Invasive Surgery, the First Hospital of Lanzhou University, Gansu, China, and others)
Chapter 4. Use of Alpha-fetoprotein and other Biomarkers for Assessing Hepatocellular Carcinoma Risk in Viral Hepatitis
Syed Abdul Basit, Mahendran Jayaraj, Christian D. Stone, Robert G. Gish (Department of Internal Medicine, Section of Gastroenterology and Hepatology, University of Nevada, Las Vegas, Nevada, USA, and others)
Chapter 5. Alpha-fetoprotein in a Protein Interaction Network: Systems Biology Approach in Discovery Biomarkers for Hepatocellular Carcinoma
N.T. Moldogazieva, A.A. Terentiev (N.I. Pirogov Russian National Research Medical University, Moscow, Russia)
Chapter 6. Alpha-fetoprotein in Malignant Pediatric Tumors
Lisa VanHouwelingen, John Sandoval (St Jude Children’s Research Hospital and Baptist Women’s and Children’s Hospital, Memphis TN, USA)
Section 2: The Role of Alpha-fetoprotein in Maternal Serum Screening
Chapter 7. Role of Maternal Serum Alpha-fetoprotein as a Screening Marker after the Introduction of Cell Free-DNA in Aneuploidy Screening
Howard Cuckle, Eugene Pergament (Columbia University Medical Center, New York, NY, USA, and others)
Chapter 8. Maternal Serum Screening in Women with Pre-existing Diseases and Congenital Disorders: Effects of Alpha-fetoprotein on False Positive Screens and Course of Disease
G.J. Mizejewski (Division of Translational Medicine, Molecular Diagnostics Laboratory Wadsworth Center, New York State Department of Health, Albany, NY, USA)
Chapter 9. Use of Alpha-fetoprotein for Detection of Preeclampsia
Jonathan B. Carmichael, David A. Krantz (PerkinElmer Labs/NTD, Melville, NY, USA)
Section 3: Alpha-fetoprotein in Adverse Outcomes and Pregnancy Complications
Chapter 10. Alpha-fetoprotein and Fetal Anemia
Jose L Bartha (Professor and Head Department of Obstetrics and Gynecology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain)
Chapter 11. Alpha-fetoprotein and Poor Pregnancy Outcomes: Observed Patterns, Pathophysiology, and Clinical Utility
Laura L. Jelliffe-Pawlowski, and Rebecca J. Baer (University of California San Francisco, CA, USA)
Chapter 12. Alpha-fetoprotein and Disorders of Placentation: Pathogenesis and Clinical Implications
Nisha Lakhi, Joanna Pessolano, Jane M. Ponterio, Michael Moretti (Department of Obstetrics and Gynecology, Richmond University Medical Center, Staten Island, NY, USA)
Section 4: Alpha-fetoprotein: Ligand Binding, Receptors, and Drugs
Chapter 13. Alpha-fetoprotein Structures, Functions and Binding Chemicals
Sugunadevi Sakkiah, Hui Wen Ng, Hao Ye, Heng Luo, Weigong Ge, Weida Tong, and Huixiao Hong (National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA)
Chapter 14. The Alpha-fetoprotein Receptor (RECAF): Characterization and Potential uses for Cancer Diagnosis and Therapy
Ricardo Moro (Program Chief and Director, Pacific Biosciences Research Centre, Richmond, British Columbia, Canada)
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Chapter 15. Alpha-fetoprotein and Recombinant Alpha-fetoprotein Fragments as Drug Delivery Tools
Galina Posypanova, Sergey Severin (National Research Center “Kurchatov Institute”, Moscow, Russia)
Chapter 16. Anti-Breast Cancer Drug Derived from Alpha-fetoprotein
James A. Bennett, Herbert I. Jacobson, Thomas T. Andersen (Center for Immunology & Microbial Diseases, Department of Obstetrics & Gynecology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA)
Chapter 17. Radiolabelling and Biodistribution Studies of GIP Peptides Derived from Alpha-fetoprotein
Michał Maurin, Piotr Garnuszek, Urszula Karczmarczyk, Ewa Laszuk, Gerald J Mizejewski (National Centre for Nuclear Research Radioisotope Centre POLATOM, Otwock, Poland)
Section 5: Alpha-Fetoprotein: Regulatory Roles, Immunotolerance, and Vaccines
Chapter 18. Cryptic epitope P149 of Alpha-fetoprotein: Role in Pregnancy and Breast Cancer
Dilip Vakharia, and Gerald Mizejewski (University of South Carolina School of Medicine, Columbia, SC, USA, and others)
Chapter 19. Alpha-fetoprotein-Mediated Immune Tolerance and its Reversal
V.N. Pak, N.N. Belyaev (freelance researcher, Toronto, Canada, and others)
Chapter 20. Engineering Alpha-fetoprotein to Develop Vaccines and T Cell Immunotherapies for Hepatocellular Carcinoma: From Preclinical Studies to Future Perspectives
Yukai He, and Sha Wu (Georgia Regents University Cancer Center, Cancer Immunology, Inflammation, and Tolerance Program, Augusta, GA, USA)
Index