Allografts: Health Benefits, Symptoms of Rejection and Treatment Challenges


Series: Surgery – Procedures, Complications, and Results
BISAC: MED085070

This book represents a refreshing and broad view of the nature of allografts, as well as the challenges involved in their use as critical therapy for a variety of different health problems. It is the work of a group of very talented and experienced physicians representing different medical disciplines, but all of them intimately involved with the use of allografts, presenting their distilled experience. The notion of allografts is explored in specialty areas ranging from orthopedics and thoracic surgery to kidney and liver transplantation, in an effort to identify certain common themes having to do with the immunological response to the allograft and the various methods to avoid rejection.

Chapters in this book present current challenges in the use of bone allografts in complex orthopedic procedures, in addition to dealing in depth with the use of hepatic and renal allografts in liver and kidney transplantation. Complex issues, such as the role of the immune system trying to deal with allograft acceptance or rejection on the one hand, and the presence of hepatitis B or C infection on the other hand, with the addition of the possibility of coexisting hepatocellular malignancy, are at the core of this book. The authors present the therapeutic problems seen in clinical practice and offer possible solutions, based on their extensive experience. This book will be a valuable resource to scientists involved in disciplines such as transplantation, immunology, and orthopedics, as the themes that are analyzed here cover a broad range of areas. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Simultaneous Thoracic and Abdominal Transplantation: Operative Technique, Transplant Indications and Short-Term Outcomes (pp. 1-16)
Joshua H. Wolf and Peter L. Abt (Johns Hopkins Hospital, Department of Surgery, MD, USA and others)

Chapter 2 – Revisions of Total Hip Arthroplasty Using Structural Acetabular Allografts and Reconstruction Rings (pp. 17-28)
S. Chacón-Cartaya, A. Puente-González, M. López-Pliego, A. Lázaro-Gonzálvez, J. Garcés-Castillo, J. Ribera-Zabalbeascoa and M. Moleón-Camacho (Orthopaedic and Reconstructive Surgery, Dept. of Orthopaedics. Hospital Virgen del Rocío, Seville, and Orthopaedics Surgery, Hospital Viamed Santa Angela, Seville, Spain)

Chapter 3 – Μanagement of Patients with Hepatitis B and C before and after Liver and Kidney Transplantation (pp. 29-66)
Chrysoula Pipili and Evangelos Cholongitas (Department of Nephrology, Laiki Merimna, Athens, and Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, Greece)

Chapter 4 – Allotransplantation for Malignancy (pp. 67-78)
Cataldo Doria and Ashesh Piyush Shah (Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA)

Chapter 5 – Non-Invasive Diagnosis of Acute Renal Allograft Rejection: Current Issues and Future Directions (pp. 79-110)
Helga Pawelski, Alexander Grabner, Uta Schnöckel, Michael Schäfers and Stefan Reuter (Department of Nuclear Medicine, University of Münster, Münster, Germany and others)

Chapter 6 – Liver Transplantation for Hepatocellular Carcinoma: A Western Point of View (pp. 111-136)
Dimitrios Giakoustidis, M.D., Ph.D. and Alexandros Giakoustidis, M.D., Ph.D. (Division of Transplantation, Department of Surgery, School of Health Sciences, Aristotle University of Thessaloniki, Hippokration General Hospital, Konstantinoupoleos Thessaloniki, Greece and others)

Chapter 7 – Kidney Transplantation: Health Benefits and Current Challenges (pp. 137-160)
Jared Gans, B.S. and Tatsuo Kawai, M.D., Ph.D. (Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA)

Chapter 8 – Hepatitis C Virus Infection and Liver Transplantation: Challenges in Improving Outcomes (pp. 161-174)
Georgios Tsoulfas, M.D., Ph.D., FACS and Polyxeni Agorastou, M.D., Ph.D. (Department of Surgery, Aristoteleion University of Thessaloniki, and Department of Gastroenterology, Aristoteleion University of Thessaloniki, Greece)

Chapter 9 – Influence of Allograft Bone on Osteoprogenitor Cell Metabolism and Mineralization: A Review of In Vitro and In Vivo Experimental Models and Clinical Case Reports (pp. 175-190)
Allison J. Rao, Stuart B. Goodman and R. Lane Smith (Orthopaedic Research Laboratories, Stanford University School of Medicine, Department of Orthopaedic Surgery, Stanford, CA, USA)

Chapter 10 – The Current Management of Patients with Chronic Hepatitis B and Chronic Hepatitis Delta Before and after Liver Transplantation (pp. 191-198)
Themistoklis G. Vasiliadis (Third Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece)

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