Alkaloids: Biosynthesis, Biological Roles and Health Benefits

Eduardo Sobarzo-Sánchez (Editor)
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy University of Santiago de Compostela, Spain

Series: Biochemistry Research Trends
BISAC: MED008000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book discusses a group of natural compounds that is referred to in many bibliographic references for its multiple medical and therapeutic applications, which have been carried out by civilizations in the past and continue to be used in the present. Thus, the alkaloids have been isolated from marine and terrestrial sources and human beings have had the aptitude to determine the chemical structure of many derivatives of simple and big complexity as well as observing the biological effects of every compound in the living organism.

Different natural sources as well as the synthesis of many alkaloids of big therapeutic activity have been the basis for the hundreds of drugs that are applied successfully in the scope of the health and combating diverse diseases. Alkaloids’ low cytotoxicity in many cases and versatility in transforming into stable salt have generated diverse drugs of easy administration in the organism without the side effects associated with the ingestion of organic and inorganic salt of difficult tolerance.

In this sense, this contribution covers several chapters which include: mechanisms and strategies against cancer, wherein certain types of alkaloid take control of important and selective form; the use of boldine as the alkaloid of current reference in the traditional medicine and used actively as natural antioxidant; alkaloids from vegetable origin as coming from the Amaryllidaceae; curious brominated alkaloids from marine sources between several outstanding examples; alkaloids derived from the Erythrina including the synthesis and pharmacological applications; the technological approaches of some derivatives originated from Tropane; an interesting contribution of the application of Trabectedin as alkaloid of clinical use in the treatment of ovarian cancer; the mention of a small group of alkaloids called oxoisoaporphines as the big medical tool in the treatment of mental disorders such as depression; and finally a complete review on the Daphniphyllum alkaloids.

This complete review of chapters that includes diverse nitrogenated compounds such as marine and terrestrial alkaloids that cover the future development of new vaccines as well as the clinical treatment of diseases of diverse nature, will help us to know and understand the importance and amplitude of the alkaloids and their role in our lives. The challenges that they generate towards the future, principally in the feeding and in the scope of the health will be mentioned and discussed in each chapter. (Imprint: Nova)

Preface

Targeting Mitochondrial Bioenergetics of Cancer Cells with Alkaloids: Mechanisms and Anti-Cancer Strategies
(Félix A. Urra, Ramiro Araya-Maturana, Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago de Chile, Chile)

Boldine as Antioxidant: From Farm to Pharmacy
(Seyed Fazel Nabavi, Maria Daglia, Eduardo Sobarzo-Sánchez, Seyed Mohammad Nabavi, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, and others)

Biosynthesis of Amaryllidaceae alkaloids: A Biochemical Outlook
(Aparna Singh, Isabel Desgagné-Penix, Université du Québec à Trois-Rivières, Canada, and others)

Marine Brominated Alkaloids: Isolation, Biosynthesis, Biological Activity and Synthesis
(Saeed Ahmad, Faiz Ahmed Khan, Department of Chemistry, Indian Institute of Technology Hyderabad, Ordnance Factory Estate, Yeddumailaram, India)

Erythrina Alkaloids: Recent Advances in their Synthesis, Isolation and Pharmacology
(Olimpo García-Beltrán, Miguel Moreno-Palacios, Facultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué, Ibagué, Colombia)

Biotechnological Approaches for the Improvement in the Production of Tropane Alkaloids: Implications and Medicinal Applications
(Alejandra B. Cardillo, Julián Rodríguez Talou, Ana María Giulietti, Microbiología Industrial y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina)

Bioactive Alkaloids of Marine Origin
(Anna Aiello, Concetta Imperatore, Filomena D'Aniello, Marialuisa Menna, The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Napoli, Italy)

Trabectedin: A Marine Alkaloid with Anticancer effects against Ovarian Cancer
(Seyed Fazel Nabavi, Maria Daglia, Eduardo Sobarzo-Sánchez, Seyed Mohammad Nabavi, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, and others)

Oxoisoaporphines as Medical Tool: In Treatment of Antineoplastic Diseases and Mental Disorders
(Eduardo Sobarzo-Sánchez, Seyed Mohammad Nabavi, Eugenio Uriarte Villares, Laboratory of Pharmaceutical Chemistry-Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Spain, and others)

Daphniphyllum Alkaloids
(Haifeng Wu, Xiaopo Zhang, Lisheng Ding, Shilin Chen, Xudong Xu, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, and others)

Index

This book is directed to students, academics and researchers in the scope of medicinal chemistry, pharmacology, medicine and all health career in universities and medicine and health schools.

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