Alcohol and the Liver

Gerond Lake-Bakaar (Editor)
Beth Israel Deaconess Medical Center, Harvard Medical School, Director, Liver Tumor Center, Boston, MA

Series: Hepatology Research and Clinical Developments
BISAC: MED114000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The topic of alcohol and the liver is long overdue for re-evaluation. The authors of this book have clearly taken up this challenge. Human interest in alcohol dates back to the Neolithic period (circa 10,000 BC). Only a small amount of alcohol is found naturally in food. Therefore, humans have yet to adapt to the high quantities of alcohol consumed daily by alcohol abusers. Alcohol is a simple carbohydrate and is metabolized as a fuel. However, unlike more naturally occurring carbohydrates such as glucose, the pathways for its metabolism are not subject to the same checks and balances.

Ethanol oxidation reduces NAD+, which starves reactions that depend on this substrate. This accounts for the accumulation of fat in alcoholic steatosis. Alcohol metabolism generates significant amounts of reactive oxygen species (ROS), which damages mtDNA and subsequently mitochondrial integrity. The authors provide several lines of evidence that link the clinical picture of alcoholic liver disease with mitochondrial damage. Other important topics highlighted in this book include histo-pathological aspects of the disease. Clinical assessment of nutrition and vitamin supplementation is addressed as well. The book concludes with the highly topical and controversial aspect of liver transplantation in patients with alcoholic liver disease.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Alcohol Metabolism and Alcoholic Liver Disease
(Director, Liver Tumor Center, Beth Israel Deaconess Medical Center, Associate Professor of Medicine, Harvard Medical School, Boston, MA, USA)

Chapter 2
Inflammation in Alcoholic Liver Disease
(Laura Hand & Mark A. Exley, University of Manchester, Manchester, UK, and others)

Chapter 3
Purinergic Signaling and the Inflammasome in Acute Alcoholic Liver Disease
(Paola de Adrade Mello, Trishan Vaikunthanathan, Simon C. Robson, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Brazil, and others)

Chapter 4
Assessment of Malnutrition in Alcoholic Liver Disease
(Audrey Paradis, Transplant Dietitian at Beth Israel Deaconess Medical Center, MA, USA)

Chapter 5
Vitamins and Supplements in Alcoholic Liver Disease
(Katelyn R Richards, Clinical Pharmacist – Solid Organ Transplant, Beth Israel Deaconess Medical Center, Boston, MA, USA)

Chapter 6
Liver Transplantation for Alcoholic Liver Disease
(Saikiran Kilaru, Michael P Curry, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA)

Chapter 7
Alcoholic and Nonalcoholic Fatty Liver Disease
(Gary Trey, Clinical Instructor, Harvard Medical School, Attending Physician, Beth Israel Deaconess Hospital, Boston, MA, USA)

Chapter 8
Pathologic Features and Mechanisms in Alcoholic Liver Disease
(Imad A. Nasser, E. Yee, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA)

Chapter 9
Alcohol and the Liver: Role of Mitochondria
(Alfredo Saavedra-Molina, Héctor Riveros-Rosas, Adriana Julián-Sánchez, Rocío Montoya-Pérez, Ruth Noriega-Cisneros, Instituto de Investigaciones Químico-Biológicas. Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich, México, and others)

Index

The book provides a deep understanding of all aspects of alcoholic liver disease. It should appeal to both clinicians and non-clinicians that cope daily with alcohol abusers.

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