Aggressive Breast Cancer

Regina H. DeFrina (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Breast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram, a lump or change in consistency of the breast tissue can also be a warning sign of the disease. Heightened awareness of breast cancer risk in the past decades has led to an increase in the number of women undergoing mammography for screening, leading to detection of cancers in earlier stages and a resultant improvement in survival rates. Still, breast cancer is the most common cause of death in women between the ages of 45 and 55.This new book presents the latest research in the field. (Imprint: Nova)

Contents

Preface

Research and Review Articles

Chapter 1. The HER2 Oncogene in Breast Cancer, pp. 1-52
(Myra F. Barginear, Daniel R. Budman, The Tisch Cancer Institute at the Mount Sinai School of Medicine, New York, NY, USA, and others)

Chapter 2. Multi-Drug Resistance as a Problem Challenging Breast Cancer Chemotherapy, pp. 53-100
(Samar S. Azab, Ebtehal El-Demerdash, Ayman Al-Hendy, Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt, and others)

Chapter 3 Signal Transduction and Metastasis Suppression: The Role of Raf Kinase Inhibitor Protein (RKIP) in Breast Cancer, pp. 101-120
(Zhi Yao, Rong Lu, Department of Immunology, Tianjin Medical University, Tianjin, China, and others)

Chapter 4. BRCA1-Associated Proteins: Novel Targets for Breast Cancer Radiation Therapy, pp. 121-141
(Xiaowei Chen, Jamie L. Kistler, and Andrew K. Godwin, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania)

Chapter 5. Peripheral Benzodiazepine Receptor as a Biomarker for Breast Cancer, pp. 143-158
(Sutapa Mukhopadhyay, Salil K. Das, Department of Cancer Biology, Meharry Medical College, Nashville, Tennessee)

Chapter 6. Phospholipids as Biomarkers for Breast Cancer, pp. 159-171
(Somdutta Sinha Roy, Salil K. Das, Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, Tennessee)

Chapter 7. Genetically Engineered T-Cells for Adoptive Immunotherapy of Breast Cancer, pp. 173-185
(Dinorah Friedmann-Morvinski, Victoria Marcu-Malina, Tova Waks, Zelig Eshhar, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA, and others)

Chapter 8. Trastuzumab Resistance, pp. 187-197
(E. Razis, G. Fountzilas, Asst. Div, 1st Oncology Department., “HYGEIA” Hospital, Marousi, Attiki, Greece, and others)

Chapter 9. Lymphatic Spreading Propensity and Aberrant MUC1 Bearing TN/TN-Like Carbohydrate of Aggressive Breast Cancer Cells, pp. 199-228
(Takanori Kawaguchi, Masahiko Kanno, Hiroshi Takazawa, Shunsuke Imai, Jyunji Morimoto, Satomi Haga, Takashi Honda, Department of Pathology, Aizu Central Hospital, Aizu Wakamatsu, Japan, and others)
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Commentary: Relationship between Carbohydrate Expression Profiles of Cancer Cells and Prognosis of Breast Cancer Patients, pp. 231-235
(Takanori Kawaguchi, Masahiko Kanno, Shuji Asahi, Takashi Honda, Department of Pathology, Aizu Central Hospital, Aizu Wakamatsu, Japan, and others)

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