Age-Associated Changes in Dendritic Cells and Implications for Infectious Diseases, Cancer and Inflammation

Yuping Deng (Editor)
Binera Inc., Yorktown, Virginia, USA

Series: Cell Biology Research Progress, Aging Issues, Health and Financial Alternatives
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Dendritic cells (DC) are important for initiating and regulating immune responses. While DC in general are known for their ability to take up, process and present antigen to T cells, plasmacytoid dendritic cells (pDC) are also recognized as an important cell population for their direct an-viral activity because the large amounts of type 1 interferons pDC secrete in response to viral infection.

Elderly people are more susceptible to infections and have higher morbidity and mortality from infections. Cancer and inflammation diseases are also prominent among elder people. Cancer immunotherapy using in vitro generated DC from monocytes (MODC) has shown to be feasible and safe in clinical trials with promising results. This book discusses the age-related changes in cell number, phenotype and function of dendritic cells, with pDC and myeloid dendritic cell (mDC), the two main DC subsets in particularly. (Imprint: Nova)

Abstract

I. Introduction

II. Age-Related Changes in DC: Studies in Mice

III. Age-Related Changes in DC: Studies in Humans

IV. Implications for Infectious Diseases

V. Implications for Inflammation

VI. Implications for Cancer

VII. Concluding Remarks

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