African Trypanosomiasis: Clinical Symptoms, Diagnosis and Treatment


Gerald T. Hughes (Editor)

Series: Parasites and Parasitic Diseases
BISAC: MED022090

Human African trypanosomiasis or sleeping sickness is caused by infection with the morphologically indistinguishable subspecies Trypanosoma brucei rhodesiense (in East and Southern Africa) and Trypanosoma brucei gambiense (in West and Central Africa). The disease is presently almost under control and less than 4000 cases are currently reported. In both, T. b. rhodesiense and T. b. gambiense infection, after the injection of infective metacyclic trypanosomes with tsetse fly vector saliva, the parasites establish in the skin, differentiate to the bloodstream stage and spread via the local draining lymph node into the vascular system. In this book, Chapter One presents an overview of the current epidemiology, clinical features, diagnosis and treatment options. Chapter Two provides an in-depth review of diagnostic methods for African trypanosomiasis. Chapter Three discusses the use of aminoadamantane derivatives against Trypanosoma brucei. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1. Human African Trypanosomiasis: Clinical Symptoms, Diagnosis and Treatment
Bisser S. (Institut Pasteur de la Guyane, Cayenne Cedex, France)

Chapter 2. Diagnostic Methods for African Trypanosomiasis
Jesca Nakayima (Senior Research Officer, Biotechnology section, National Livestock Resources, Research Institute of National Agricultural Research Organization, Tororo, Uganda)

Chapter 3. Aminoadamantane Derivatives against Trypanosoma bruce
Ioannis Papanastasiou, George B. Foscolos, Andrew Tsotinis, and John M. Kelly (School of Health Sciences, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, Athens, Greece, and others)



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