Advances in Studies on Enzyme Inhibitors as Drugs. Volume 1: Anticancer and Antiviral Drugs


Satya P. Gupta (Editor)
Professor Emeritus, National Institute of Technical Teacher’s Training and Research, Bhopal, India

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

The book Advances in Studies on Enzyme Inhibitors as Drugs edited by eminent scientist Satya P. Gupta, covers the most recent development on design and discovery of the most useful drugs acting against several life threatening diseases such as cancer, viral infections and many others in two volumes. All of these drugs are based on inhibitions of various enzymes. Most human diseases are found to be associated with the overexpression of the enzymes. The book presents the structural aspects of various enzymes, their active sites, and the structural requirements of chemicals for strong interactions with enzymes. Volume One contains twelve chapters related to enzyme inhibitors acting as anticancer and antiviral drugs (each written by highly acclaimed authors), and Volume Two contains ten chapters on enzyme inhibitors acting against miscellaneous diseases written by equally competent authors. The book may be an asset for drug industries, research organizations, and individual researchers. (Imprint: Nova Biomedical)



Table of Contents



Chapter 1. Mitogen-Activated Protein Kinase (MAPK) Inhibitors for The Treatment of Advanced Hepatocellular Carcinoma
Srikanta Dash, Srinivas Chava, Yucel Aydin, Joseph J. Buell, Tong Wu, Ari J. Cohen, Luis A. Balart (Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, Lousiana, United States of America, and others)

Chapter 2. Protein Farnesyltransferase Inhibitors as Novel Anticancer Chemotherapeutics
Manish K. Gupta, Dheeraj Kumar Sharma and Ravindra K. Rawal (School of Pharmacy, Lloyd Institute of Management and Technology, Knowledge Park-II, Greater Noida-201306, UP, India, and others)

Chapter 3. Peptidylarginine Deiminase (PAD) Inhibitors
Adam Koebel, Elizabeth Joanne Curiel Tejeda, Rhonda Tu, and Lakshmi P. Kotra (Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 4. Interfering with Enzymatic Steps of Micrornas Pathway Using Small Molecules
Maria Duca, Université Côte d’Azur (Institute of Chemistry of Nice UMR7272 CNRS, Faculté des Sciences, Parc Valrose, Nice, France)

Chapter 5. In Silico Studies for the Discovery of Leads to Inhibit Cyclin-Dependent Kinase 2 (CDK2)
Murali Aarthy, Singaravelu Usha and Sanjeev Kumar Singh (Computer Aided Drug Design and Molecular Modelling Lab, Department of Bioinformatics, Science campus, Alagappa University, Karaikudi, India)

Chapter 6. Design and Development of Tyrosine Kinase Inhibitors as Anticancer Drugs
Basheerulla Shaik, Satya P. Gupta and Vijay K. Agrawal (Department of Applied Sciences, National Institute of Technical Teachers’ Training & Research, Shamla Hills, Bhopal, Madhya Pradesh, India, and others)

Chapter 7. In Silico Design of Carbonic Anhydrase Inhibitors as Antitumor Drugs
Shalini Singh, Basheerulla Shaik and Satya P. Gupta (QSAR & Cheminformatics Laboratory, Department of Chemistry, Bareilly College, Bareilly,(U.P.) India, and others)


Chapter 8. Studies on Inhibitors of Dengue Virus Protease
Venkatesan Jayaprakash, Ajay Kumar Timiri and Barij Nayan Sinha (Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India)

Chapter 9. Design and Development of Inhibitors of Picornavirus Proteases
Debasis Das (Department of Chemistry, Sree Chaitanya College, Habra, Parganas, West Bengal, India)

Chapter 10. Neuraminidase Inhibitors: From Research Tools to Drug Candidates
Vaishali M. Patil and Satya P. Gupta (Department of Medicinal Chemistry, Kharvel Subharti College of Pharmacy, Swami, Vivekanand Subharti University, Subhartipuram, Meerut, India, and others)

Chapter 11. Recent Developments in HIV-1 Integrase Inhibitors
Utsab Debnath and Seturam B. Katti (Medicinal and Process Chemistry Division,CSIR-Central Drug Research Institute, Lucknow, India)

Chapter 12. Studies on Dual Inhibitors of HIV Reverse Transcriptase and Integrase
Subramanian Karunagaran, Ramanathan Shylaja and Chandrasekaran Meganathan (Department Physics, G.K.M. College of Engineering & Technology, Alapakkam, Mappedu Road, Perungalathur, Tamil Nadu, India)

About the Editor


Additional information