Advances in Medicine and Biology. Volume 180


Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology

BISAC: MED000000

This monograph contains six chapters, each of which provides details about recent advancements in the field of medicine and biology. Chapter One describes the discovery of AZQ, a drug specifically designed to shut off genes that cause brain cancer. Chapter Two analyzes the structure, stability, adaptation to extreme environments and the catalytic mechanism of α-helical membrane proteins. Chapter Three provides an up-to-date overview of artificial intelligence (AI) in assisted reproductive treatment (ART) clinics and explores how AI learns and develops a dataset to provide clinical guidance. Chapter Four consists of a study focused on the etiopathogenesis of primary open angle glaucoma using laboratory mice. Chapter Five presents and comments on the current evidence regarding diagnostics in patients with metastatic breast cancer based on circulating tumor cells (CTCs). Lastly, Chapter Six reviews the pathogenetic and clinical features of inner ear involvement in congenital cytomegalovirus (cCMV), the most frequent non-genetic cause of permanent sensorineural hearing loss in childhood.

Table of Contents


Chapter 1. The Impact of Sequencing Human Genome on Genomic Medicine and the Discovery of AZQ (US Patent 4,146,622) Specifically Designed to Shut Off Genes that Cause Brain Cancer
(Hameed Khan, PhD – Washington, DC, US)

Chapter 2. CU(I)-Transport ATPases. Molecular Architecture, Catalysis and Adaptation to Extreme Environments
(Alvaro A. Recoulat Angelini, M. Agueda Placenti, Noelia A. Melian, M. Lurdes Sabeckis, Noelia I. Burgardt, Rodolfo M. González Lebrero, Ernesto A. Roman and F. Luis González Flecha – Universidad de Buenos Aires, CONICET. Laboratorio de Biofísica Molecular. Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina)

Chapter 3. The AI Doctor Will “See” You Now: Are Doctors and Embryologists No Longer Indispensable in Assisted Reproductive Treatment (ART)?
(Kailin Yap and Joo P. Teoh – Genea Hollywood Fertility, Perth, WA, Australia)

Chapter 4. Search for New Theories of Etiopathogenesis of Primary Open Angle Glaucoma: Features of Level of Intraocular Pressure and Number of Retinal Ganglion Cells in Conditions of Genetic Defect of Different Subtypes of A1-Adrenoreceptors
(N. V. Korsakova and E. I. Korsakova – Chuvash State University, Cheboksary, Russian Federation, et al.)

Chapter 5. Circulating Tumor Cells in Metastatic Breast Cancer: Ready for Clinical Practice?
(Maggie Banys-Paluchowski, Donata Grimm, Achim Rody, Peter Paluchowski and Natalia Krawczyk – Department of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Lübeck, Lübeck, Germany, et al.)

Chapter 6. Inner Ear Involvement in Congenital Cytomegalovirus Infection
(Giulia Bianchi, Virginia Corazzi, Chiara Bianchini, Stefano Pelucchi and Andrea Ciorba – ENT & Audiology Department, University Hospital of Ferrara, Cona FE, Italy)


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