Advances in Medicine and Biology. Volume 168


Leon V. Berhardt

Series: Advances in Medicine and Biology
BISAC: MED000000

The role of CYP2D6 in the pharmacokinetic and/or pharmacodynamic differences in opiates and opioid consumers is discussed, as well as the associated genetic implications and consequences in the scope of clinical and forensic toxicology. Studies conducted on postmortem pharmacogenetic cases are investigated, and the benefits of CYP2D6 profiling during forensic investigations are discussed. The authors discuss recent advances in the split crest technique, underlining the importance of soft tissue management, especially at the level of the upper jaw where bone augmentation may be sufficient to install dental implants, but soft tissue grafting is necessary to achieve adequate aesthetic results. Hyaluronan or hyaluronic acid, an extracellular polysaccharide usually found associated with the cell surfaces, is explored. The subsequent article deals with the various stages, pathology, etiology and recent treatments associated with rheumatoid arthritis. Additionally, a comparative survey of current cardiovascular imaging practices/methodologies is provided, including magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasonography.
The closing study highlights the fundamentals of pharmaceutical gels, their morphological and rheological properties, formulation considerations, and analytical and stability aspects.

Table of Contents

Table of Contents


Chapter 1. The Role of CYP2D6 in Opiates and Opioids Consumers and Its Implications in Clinical and Forensic Toxicology
(Mónica Antunes, Ana Y. Simão, Suzana Fonseca, Joana Gonçalves, Sofia Soares Ema Almeida, Carina Gameiro, Tiago Rosado, Ana Paula Duarte, PhD, Mário Barroso, PhD, André R. T. S. Araújo, PhD, Jesus Rodilla, PhD, and Eugenia Gallardo, PhD, Laboratório de Fármaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Covilhã, Portugal, and others)

Chapter 2. Forensic Perspective of CYP2D6 Polymorphism
(Selda Mercan, PhD, Institute of Forensic Sciences and Legal Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey)

Chapter 3. New Progress and Limits in the Split Crest Technique for Implant Rehabilitation
(Celia Vázquez-Pachón, DDS, Cristina Aguilar-Megías, DDS, Ramón Gómez-Meda, DDS, María-Ángeles Serrera-Figallo, DDS, PhD, and Daniel Torres-Lagares, DDS, PhD, Dentistry Department, Dental School, University of Seville, Seville, Spain)

Chapter 4. Hyaluronan: Role in Biological and Pathological Processes
(Chitrakshi Consul and Sonu Chand Thakur, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India)

Chapter 5. Rheumatoid Arthritis: Pathological Mechanisms and Pharmacologic Therapies
(Shiereen Fatima and Sonu Chand Thakur, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India)

Chapter 6. A Comparative Survey on State-Of-The-Art Medical Imaging Methodologies for Heart Monitoring
(Garrett G. Goodman and Nikolaos G. Bourbakis, Department of Computer Science and Engineering, Wright State University, Dayton, OH, US, and others)

Chapter 7. Pharmaceutical Gels: Morpholigical, Rheological, Manufacturing, Analytical and Stability Aspects
(Sidra Hassan, Mirza Tasawar Baig, Maria Ashfaq and Adeel Arsalan, Department of Pharmaceutics, Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan, and others)


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