Advances in Medicine and Biology. Volume 165


Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: SCI008000

Advances in Medicine and Biology. Volume 165 first presents promising information about the essential goal of effective and safe medication for target patients with the appropriate genotypes.

The authors explore the diverse causes of neonatal leukemoid reaction in premature infants proposed by Hill and Duncan in 1941, such as intrauterine infection and maternal steroid administration.

This compilation also explores hjypoxia-inducible factor-1, a key gene regulator for cellular adaptation to hypoxia which leads to a transcriptional response under physiological as well as pathological conditions.

From a historical perspective, Wilms’ tumor treatment is assessed, focusing on the different approaches of the two main groups, the Children’s Oncology Group and the International Society of Paediatric Oncology.

The genetics and genomics of Plasmodium, which include multiple parameters and factors affecting disease transmission, are assessed in an effort to enhance our knowledge about the disease.
Following this, whole slide imaging or virtual microscopy is used for the quantitative evaluation of liver biopsy specimens of patients with chronic hepatitis.

The closing study examines data which reveals changes in the functioning of the ceruloplasmin/transferrin system, decreasing the content of toxic ions of Fe2+ in the plasma of patients with Parkinson’s disease. These changes are a pathogenetically significant factor of Parkinson’s disease at all stages.

Table of Contents

Table of Contents


Chapter 1. Pharmacogenetics and Pharmacogenomics: A Combinatorial Genetic and Computational Approach for the Drug Development
(Karthikeyan Muthusamy, Manikandan Selvaraj, Lakshmanan Loganathan and Kannan Rajendran, Pharmacogenomics and CADD Lab, Department of Bioinformatics, Alagappa University, Karaikudi, TamilNadu, India, and others)

Chapter 2. The Mechanism of Onset in Neonatal Leukemoid Reaction: Synergistic Effect of Proinflammatory Cytokines Including Interleukin-6
(Toshihiko Nakamura, Department of Neonatology, Japanese Red Cross Musashino Hospital, Tokyo, Japan)

Chapter 3. HIF Regulation under Nonhypoxic Conditions by Kinase Cascades
(Aaishwaryadevi B. Deshmukh, PhD, and Bharat Mishra, PhD, Department of Pharmacology, Savitribai Phule Pune University, Pune, Maharashtra, India, and others)

Chapter 4. Treatment of Wilms Tumor
(Ugur Demirsoy, MD, Department of Pediatric Oncology, Kocaeli University, Kocaeli, Turkey)

Chapter 5. Plasmodium: Genomics and Genetics
(Taru Singh, PhD, and Saurabh Singh, Department of Microbiology, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India, and Research Scholar, Department of Mechanical Engineering, Delhi Technological University, Delhi, India)

Chapter 6. Digital Microscopy: Application to Liver Biopsy
(Ivan B. Tokin, Ivan I. Tokin and Galina F. Filimonova, St. Petersburg State University, St. Petersburg, Russia, and others)

Chapter 7. The Change in the Antioxidant Ceruloplasmin/Transferrin System of Blood in Parkinson’s Disease
(Marina G. Makletsova, Galina T. Rikhireva, Vsevolod V. Poleschuk, Guzel R. Urasgildeeva and Sergei N. Illarioshkin, Don State Technical University, Rostov-on-Don, Russia, and others)


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