Advances in Medicine and Biology. Volume 161

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000, SCI008000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Advances in Medicine and Biology. Volume 161 first discusses the relationship between varicocele and sperm DNA methylation status. Varicocele is a major cause of male infertility where increased testicular temperature, oxidative stresses, abnormal chromatin packaging and reduced DNA methylation account for reduced sperm quality.

The authors also discuss the use of reproductive biotechniques in the equine species, particularly artificial insemination, which dates back to the end of the 19th century and is widely used around the world today.

Following this, the principle mechanisms behind and the potential clinical applications of histotripsy are explored. In histotripsy, there are two different methods of creating pure mechanical damage of soft tissue: ultrasound cavitation or shock wave heating and millisecond boiling.

Direct and indirect targets likely associated with Cdc42 activation are highlighted, which demonstrate potential for further investigation in DNA damage-associated events.

The authors review the exact mode of action of old and new anti-seizure molecules, as well as the benefits, concerns and latest recommendations for rational and appropriate antiepileptic drug therapy.

Later, the abstract thinking regarding the constraint-based notion of systems biology is applied to the scientific field of clinical cardiology. Constraint-based thinking with downward causation is an important holistic concept of systems biology, explaining many aspects of all biological entities.

The concluding study is focused on the structure, regulation and functions of PPP ser/thr phosphatases in higher plants. This functional characterization is accompanied by structural and biochemical data.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Alteration of Sperm DNA Methylation in State of Varicocele
(Mohammad Hossein Nasr-Esfahani, PhD, Marziyeh Tavalaee, PhD, and Maurizio Dattilio, Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran, and others)

Chapter 2. Equine Semen Biotechnology
(Gustavo R. Larentis and Henrique B. A. Bastos, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil)

Chapter 3. Mechanical Ablation Using High-Intensity Focused Ultrasound
(Ki Joo Pahk, Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea)

Chapter 4. The CDC42 Signaling Pathway and Genomic Stability in Diseases
(Luiz Eduardo da Silva and Fábio Luis Forti, Department of Biochemistry, University of São Paulo, São Paulo, SP, Brazil)

Chapter 5. Antiepileptic Drugs in the Treatment of Neurological Diseases
(Łagan-Jędrzejczyk Urszula, Kowalska Marta, Prendecki Michał, Kozubski Wojciech and Dorszewska Jolanta, Chair and Department of Neurology, Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland)

Chapter 6. Systems Biology and Constraint-Based Downward Causation in Medical Clinical Practice: A Perspective Concept for Cardiology
(George E. Louridas and Katerina G. Lourida, Department of Cardiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, and others)

Chapter 7. PPP Family of Serine/Threonine Protein Phosphatases: Key Players in Plant Development and Adaptive Responses
(María Noelia Muñiz García, Juan Ignacio Cortelezzi, Iara Marlene Grobly and Daniela Andrea Capiati, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular “Dr. Héctor N. Torres”, INGEBI, CONICET, Buenos Aires, Argentina)

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