Advances in Medicine and Biology. Volume 157

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Advances in Medicine and Biology. Volume 157 opens with a study wherein the authors use guinea pig airway smooth muscle to demonstrate that testosterone blocks L type voltage dependent Ca2+ channels. Furthermore, in vivo experiments with sensitized guinea pigs show that bronchospasm induced by antigenic challenge was abolished by testosterone and its 5α and 5β-dihydrotestosterone metabolites.

Following this, the authors evaluate the structural features of skeletal muscles in children and adults with various pathologies of the musculoskeletal system based on ultrasonography, considering periods of natural growth and involutive changes.

An overview of the current state of research on fluoxetine for the treatment of anxiety alone or combined with depression is provided, along with its possible side effects.

Also provided is scientific information is regarding the neurobiological bases of depression and therapeutic effects of fluoxetine during the different periods of menopause. This information could be useful in pharmacological strategies for the treatment of depression occurring in the menopausal women.

One chapter focuses on how improved direct access to the liver protected inside the rib cage can be obtained in laparoscopic liver resection using its specific “Caudal approach”, decreasing the risk of refractory ascites and liver failure, especially in hepatocellular carcinoma patients with chronic liver diseases.

The nucleolus is packed with proteins involved in ribosome function and biogenesis, as well as other proteins involved in cell-cycle regulation, senescence and stress response. However, little is known about the molecular mechanism of protein turnover in the nucleolus. As such, the authors discuss the nucleolus-localized protein degradation pathway, which is essential to ribosome production and cell-cycle progression.

The concluding chapter focuses on the dye Congo red, which is used as a stain in microscopy to detect an abnormal material called amyloid. Amyloid consists of misfolded proteins that form fibrils which bind molecules of Congo red and orientate the molecules parallel to the long axis of the fibrils.

(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Airway Smooth Muscle Functioning in Basal, Agonists Stimulated Conditions and Novel Androgen Asthma Therapy
(Luis M. Montaño, PhD, Edgar Flores-Soto, PhD, Bettina Sommer, PhD, Héctor Solís Chagoyán, PhD, Mercedes Perusquía, PhD, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, CDMX, México, and others)

Chapter 2. Ontogenetic Approach in Muscle Structure in Vivo Evaluation in Surgical Treatment of Musculoskeletal System Pathology (Congenital Limb Deficiency: Non-Specific Infectious Spinal Diseases)
(Liudmila A. Grebenyuk, Andrey V. Gryaznykh, Anna V. Nenasheva and Egor Ya. Kochnev, Laboratory of Purulent Osteology, Federal State Budgetary Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics of the RF Ministry of Healthcare, Kurgan, Russia, and others)

Chapter 3. Anxiolytic Effects of Fluoxetine in Preclinical and Clinical Research
(J. Cueto-Escobedo, PhD, F. García-García, PhD, G. Guillén-Ruiz, PhD, and J.F. Rodríguez-Landa, PhD, Departamento de Investigación Clínica y Traslacional, Instituto de Ciencias de la Salud, Universidad Veracruzana, Xalapa, Veracruz, México, and others)

Chapter 4. Antidepressant Effects of Fluoxetine in Natural and Surgical Menopause: Preclinical and Clinical Research
(Oscar Jerónimo Olmos-Vázquez, María de Jesús Rovirosa-Hernández, PhD, Frank Pulido-Criollo, Cesar Soria-Fregozo, PhD, Prakash Thangavel and Juan Francisco Rodríguez-Landa, PhD, Programa de Doctorado en Neuroetología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, México, and others)

Chapter 5. Laparoscopic Liver Resection for the Treatment of Hepatocellular Carcinoma
(Zenichi Morise, MD, PhD, Professor and Chairman, Department of General Surgery, Fujita Health University School of Medicine, Japan)

Chapter 6. Def-CAPN3 Protein Degradation Pathway in the Nucleolus and Its Role in Digestive Organ Development
(Delai Huang and Jinrong Peng, Department of Biology, University of Virginia, Charlottesville, VA, US, and others)

Chapter 7. Misunderstood Application of Birefringence in Everyday Medical Practice: Amyloid Stained by Congo Red
(Alexander J. Howie, Department of Pathology, University College London, London, England)

Index

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