Advances in Medicine and Biology. Volume 152


Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

In this compilation, the authors first describe the combined negatively-biased and unbiased cocaine conditioning procedure, aiming to study the potential influence of the initial spontaneous exploratory bias on subsequent cocaine conditioning.

Next, the authors perform a critical review about the efficacy of mirtazapine in the treatment of substance dependence and anxiety and related disorders in order to help clinicians, pharmacists and other healthcare workers.

Transurethral drug delivery is reviewed, as well as and the application of ketorolac as an intravesical therapy. Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug and a potent analgesic.

The authors go on to discuss current trends in re-innervating functional muscle transfers and the neurophysiological basis for these various techniques.

Later, the microglial response to the process of motoneuronal cell death is analyzed by using ionized Ca2+ binding adapter molecule-1 and cFms as microglial markers.

Immunohistochemical analysis demonstrates that the number of anti-Iba1 antibody-staining cells increased in the axotomized facial nucleus during 3-5 days post-insult.

In the penultimate chapter, a detailed examination was performed of facial muscle innervation by the terminal branches of the facial nerve, in particular the microanatomical distribution to the orbicularis oculi muscle and orbicularis oris muscle.

The final study discusses the advantages and concerns related to the use of biofilm reactors for the production of high-value products, and the current challenges to establish E. coli biofilms as a valuable platform to produce recombinant proteins.

Table of Contents

Table of Contents


Chapter 1. Influence of Previous Exploratory Bias in the ‘Combined Negatively-Biased and Unbiased’ Cocaine Conditioned Place Preference Protocol
(Fabiola Ávila Gámiz, Sara Gil Rodríguez, M. Carmen Mañas Padilla, Luis J. Santín, PhD, Estela Castilla Ortega, PhD, Institute of Biomedical Research in Malaga, Spain, and others)

Chapter 2. Potential Uses of Mirtazapine in Substance Use Disorders, Anxiety and Related Disorders
(Cláudia Loureiro, Norberto Cardoso, M. Barroso, PhD, and E. Gallardo, PhD, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal, and others)

Chapter 3. Transurethral Drug Delivery and the Application of Ketorolac as an Intravesical Therapy
(Anna M. Mainwaring and Hrishi B. Joshi, MD, Department of Urology, University Hospital of Wales, Cardiff, United Kingdom)

Chapter 4. Current Trends in Functional Muscle Transfer to Improve Outcomes in Facial Reanimation Surgery
(Ioana Lese, MD, and Adriaan O. Grobbelaar, PhD, Department of Plastic, Aesthetic and Reconstructive Surgery, Inselspital, Bern University, Bern, Switzerland, and other)

Chapter 5. Response of Microglia to Motoneuron Cell Death in Axotomized Infant Rat Facial Nucleus
(Maasa Koshimoto,Takashi Ishijima and Kazuyuki Nakajima, Department of Science and Engineering for Sustainable Innovation, Faculty of Science and Engineering, Soka University, Tokyo, Japan)
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Chapter 6. Clinical Anatomy of the Facial Nerve Palsy
(Hiroshi Moriyama and Nobuyuki Mitsukawa, Department of Anatomy, Showa University, School of Medicine, Tokyo, Japan, and others)

Chapter 7. Production of Recombinant Proteins in Escherichia coli Biofilms: Challenges and Opportunities
(L. C. Gomes and F. J. Mergulhão, Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, Porto, Portugal)


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