Advances in Medicine and Biology. Volume 149

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This collection begins by discussing bendamustine, a nitrogen mustard derivative that consists of a meclorethamine group, butyric acid and a benzimidazole ring. Bendamustine has been synthesized in 1963, but in recent years it has been shown to be effective in treating lymphoproliferative diseases and solid tumors.

Additionally, the authors present the efficacy of structure variation of bendamustine for the enhancement of the lipid membrane partitioning and tissue penetration, as well as drug-likeness. A total of 10 novel compounds are presented, wherein seven have higher Log P values and three have lower Log P values than that of bendamustine.

Advances in Medicine and Biology. Volume 149 also discusses metabolic syndrome, a growing major clinical challenge for global health resultant from over-consumption of energy and obesity.

Following this, the authors address the importance of antimicrobial resistance in human and veterinary medicine, focusing on antimicrobial peptides such as nisin as therapeutic alternatives.

A study is presented wherein it is concluded that oligodendrocyte dysfunction in multiple system atrophy significantly affects subcortical anatomical pathways. Moreover, the spatial patterns of the glial cytoplasmic inclusions in multiple system atrophy contrast with those reported for filamentous neuronal inclusions in other neurodegenerative diseases.

Next, the authors summarize the recent discoveries expounding how β-cell identity and heterogeneity evolve in diabetes mellitus, discussing a new perspective of β-cell function salvage in diabetes mellitus development.

Yeast cell cycle arrest and its consequences are analyzed in the subsequent chapter. Cell cycle arrest results in programmed cell death, such as apoptosis, wherein cells are made to commit suicide.

The penultimate study evaluates the effect of anodal transcranial direct current stimulation on cognitive and neurophysiological functions in patients with moderate cognitive impairment.

Lastly, to investigate the role of CD44 in the development of allergic respiratory inflammation, a mouse model of airway allergic inflammation induced by transnasal administration of helminthic and mite allergens is used to analyze bronchoalveolar lavage fluid and airway hyper responsiveness.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Bendamustine: Structure, Metabolism, Clinical Efficacy and Toxicity
(Semra Paydas, MD, Department of Medical Oncology, Cukurova University Faculty of Medicine, Adana, Turkey)

Chapter 2. Modification of Bendamustine Structure to Enhance Tumor Penetration And Drug-Likeness
(Ronald Bartzatt, University of Nebraska at Omaha, Durham Science Center, Omaha, Nebraska, US)

Chapter 3. Metabolic Syndrome and the Immune System
(Beatriz da Silva Rosa Bonadiman, MD, Eduardo Ottobelli Chielle, PhD, and Margarete Dulce Bagatini, PhD, Department of Biological Sciences - Biochemistry, University Federal State Santa Catarina, Florianópolis, SC, Brazil, and others)

Chapter 4. Fighting Antimicrobial Resistance: The Biomedical Use of the Antimicrobial Peptide Nisin
(Eva Cunha, Luís Tavares, Ana Salomé Veiga and Manuela Oliveira, Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, and others)

Chapter 5. A Quantitative Study of the Glial Pathology in the Synucleinopathy Multiple System Atrophy
(R. A. Armstrong, Deptartment of Vision Sciences, Aston University, Birmingham, England)

Chapter 6. Rediscovered Identity of β-Cells: Heterogeneity, Transdifferentiation and Dedifferentiation
(Mingchao Jiang, Ling Gao and Yingjie Wu, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China, and others)

Chapter 7. The Role of Cell Cycle Arrest in Determining Cell Fate in Yeast
(Suhyun Kim and Dong Gun Lee, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu, Korea)

Chapter 8. The Role of Transcranial Direct Current Stimulation in Patients with Moderate Cognitive Impairment
(A. Gangemi, B. Colombo and R. A. Fabio, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy, and others)

Chapter 9. Critical Role of CD44 in T Helper Type 2-Mediated Eosinophilic Airway Inflammation in a Mouse Model of Acute Asthma
(Shigeki Katoh, MD, Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan)

Index

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