Advances in Medicine and Biology. Volume 147

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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The first chapter of Advances in Medicine and Biology. Volume 147 reviews actions on bone longitudinal growth, muscle, kidney, calcium, nitrogen, phosphorus and potassium, body composition, carbohydrate metabolism, insulin, lipids, protein actions, coagulation and fibrinolysis, adipokines, cardiovascular effects, and retina.

Next, the authors discuss the values and boundaries of various surgical approaches to achieve interbody fusion, and introduce a novel fusion technique named extraforaminal lumbar interbody fusion.

Each indirect decompression procedure for the intervertebral foramen is introduced in detail, and their influence on intervertebral foramen parameters is discussed, including foraminal height and foraminal area. This provides detailed information on the quantitative decompression index, thus proving helpful for surgeons.

Following this, prodrugs are examined, having been extensively studied in the field of drug development. Continuous research in developing prodrugs/drug conjugates has resulted in an improvement of the lipophilicy, aqueous solubility, oral bioavailability, chemical stability, prolongation of action, reduced toxicity and site specific drug delivery of parent drugs.

The susceptibility of germline stem cells to genetic damage induced by oxaliplatin and its mechanism of action is also discussed. Germ cells are responsible for the transmission of genetic information from males to their progeny.

The authors evaluate parenteral nutrition-associated liver disease and how it encompasses a variety of diseases ranging from steatosis to fibrosis and cirrhosis.

A systematic review of the literature is executed to pool data from all individually documented patients to evaluate the safety and efficacy of combined liver and inferior vena cava resection in patients with colorrectal liver metastases involving inferior vena cava.

Research in subsequent chapter examines how the development of purkinje cells in the postnatal period in rats is accompanied by significant structural and metabolic changes, this being the basis for their growth, maturation, differentiation and functions.

The authors evaluate the in vitro leishmanicidal activity of the Vanillosmopsis arborea essential oil and its major compound𝛼-bisabolol against Leishmania amazonensis in an effort to evaluate its role to treat diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis.

Since there are still only few data available for the understanding of cellular and molecular functions of Neurensin genes in spite of the expected critical roles in human brain function, the authors present studies which will contribute to elucidating the mechanism of brain disorders at the molecular level.

The concluding chapter focuses on the pharmacokinetic/pharmacodynamic properties of emtricitabine, dosing recommendations, and monitoring in the oral antiretroviral preexposure prophylaxis population.
(Imprint: Nova Medicine and Health)


Chapter 1. Clinical Actions of Growth Hormone (GH)
(Isabel Ruiz-Sánchez, María Dolores Cañete, Ignacio Ortea, and Ramón Cañete, Universidad de Córdoba, Córdoba, Spain, and others)

Chapter 2. Extraforaminal Lumbar Interbody Fusion (ELIF)
(Yongchao Li, Mingjie Yang, Xiaofei Feng, Shuaifeng Yan, Jie Pan, Lijun Li, and Jun Tan, Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China, and others)

Chapter 3. Indirect Decompression of Intervertebral Foramen under Lumbar Interbody Fusion
(Shuaifeng Yan, Kai Zhu, Yongchao Li, Qihang Su, Mingjie Yang, Jie Pan, Lijun Li, and Jun Tan, Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China, and others)

Chapter 4. Prodrugs: An Advanced Approach for the Drug Development to Enhance the Therapeutic Efficacy
(Ritika Srivastava, Farha Naaz, Madhu Yadav, Vishal Kumar Singh, and Ramendra K. Singh, Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj, India)

Chapter 5. Sensitivity of Spermatogenic Cells to the Induction of DNA Damage by Oxaliplatin in Vitro
(Khaled Habas, Martin. H. Brinkworth, and Diana Anderson, Faculty of Life Sciences, University of Bradford, Bradford, West Yorkshire, UK)

Chapter 6. Parenteral Nutrition-Associated Liver Disease (PNALD): An Appraisal for Neonatologists and Pathologists
(Sergi M. Consolato, MD, PhD, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada, and Stollery Children’s Hospital, Edmonton, AB, Canada)

Chapter 7. Surgery of Colorrectal Liver Metastases Involving the Inferior Vena Cava
(Mario Serradilla-Martín, MD, Pablo Ruíz-Quijano, MD, Ana Palomares-Cano, MD, and José M. Ramia-Ángel, MD, PhD, Department of Surgery, Miguel Servet University Hospital, Zaragoza, Spain, and others)

Chapter 8. Postnatal Development of Purkinje Cells in Rats
(S.M. Zimatkin, and O.A. Karnyushko, Grodno State Medical University, Grodno, Belarus)

Chapter 9. In Vitro Interaction of the Vanillosmopsis arborea Baker (Asteraceae) Essential Oil and Its Major Constituent α-Bisabolol with Leishmania amazonensis Parasites
(Aracelio Viana Colares, Fernando Almeida-Souza, Maria Karollyna do Nascimento Silva Leandro, Henrique Douglas Melo Coutinho, Jaime Ribeiro-Filho, Noemi Nosomi Taniwaki, Celeste da Silva Freitas Souza, José Galberto Martins da Costa, Kátia da Silva Calabrese, and Ana Lúcia Abreu-Silva, Leão Sampaio University Center, UNILEAO, Juazeiro do Norte, Ceará, Brazil, and others)

Chapter 10. Neurensin1 and Dendrite Formation of the Developing Purkinje Cells: The Overall Perspective on the Cell and Molecular Nature of Nrsn1
(Masasuke Araki, Keiko Kiyonaga-Endou, Manabu Oshima, and Kazuya Sugimoto, Unit of Neural Development and Regeneration Research, Department of Biology, Nara Medical University, Kashihara, Nara, and others)

Chapter 11. Emtricitabine as part of HIV Preexposure Prophylaxis (PrEP)
(Leyannie Hernandez, and Olga M. Klibanov, Wingate University School of Pharmacy, Wingate, North Carolina, USA)


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