Advances in Medicine and Biology. Volume 146

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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In Advances in Medicine and Biology. Volume 146, the authors begin by exploring the mammalian eye lens, a unique transparent organ, with a distinctive cellular architecture and polarity. For more than a century, it has been used as a model to study mechanisms of induction, morphogenesis, differentiation and disease.

Following this, the authors discuss guanylate-binding protein-1 (GBP-1), an interferon-inducible large GTPase involved in the epithelial barrier and cell proliferation. Induction of GBP-1 by proinflammatory cytokines is regulated via various signaling pathways and is a reliable marker of interferon-γ-activated cells in various diseases.

This compilation also examines remifentanil, a synthetic fentanyl derivative and ultra-short acting, selective µ-opioid receptor agonist. Its chemical structure includes a methyl-ester ring that allows its hydrolysis by non-specific plasma and tissue esterases.

The authors suggest that the role of sevoflurane in preventing oxidative damage and inflammatory response to ventilator injury-induced lung injury requires further investigation. Sevoflurane is a halogenated anaesthetic developed in the early ‘70s which preserves the hypoxic vasoconstriction reflex, doesn’t irritate the airways, and maintains self-regulation of the district circles.

Additionally, the current knowledge on immune-checkpoint inhibitors, immune mediated hepatitis and pancreatitis is summarized. Immune-checkpoint inhibitors continue to revolutionize cancer therapy and are expected to be utilized in an increasing number of malignancies in the coming years.

The closing chapter discusses vitamin E, a collective term including compounds which are either naturally occurring or synthetic analogues exhibiting the biological activity of vitamin E. Vitamin E is a micronutrient and fat-soluble vitamin which has an important role in human beings, particularly children.
(Imprint: Nova Medicine and Health)


Chapter 1. The Ocular Lens Epithelium: Modelling Growth Factor Signalling in Physiological and Pathological Conditions
(Frank J. Lovicu, PhD, Tayler F. L. Wishart, Brooke P. Mao, Mary Flokis, Fatima Wazin and Daisy Y. Shu, PhD, Disciplines of Anatomy and Histology, Bosch Institute, and Ophthalmology, Save Sight Institute. The University of Sydney. Sydney, Australia)

Chapter 2. Guanylate Binding Protein-1-Mediated Epithelial Barrier via Tight Junctions
(Takumi Konno, Takayuki Kohno, Kenichi Takano, Ryo Miyata, Maki Miyakawa, Hiroki Tanaka and Takashi Kojima, Department of 1Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, and others)

Chapter 3. Role of Remifentanil in the Success of Fast-Track Anesthesia
(Paola Aceto, Cinzia Dello Russo, Giovanni Punzo, Ersilia Luca, Maria Antonietta Crea, Cristina Modesti, Teresa Sacco, Roberto De Cicco, Antonella Tosi, Ina Ceaichisciuc, Irene Marusco, Chiara Schipa, Francesco D’Angelo, Valter Perilli and Liliana Sollazzi, Department of Anesthesiology and Intensive Care Medicine, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy, and others)

Chapter 4. New Insights from Researches about Sevoflurane Anaesthesia
(Paola Aceto, Antonella Tosi, Giovanni Punzo, Roberto De Cicco, Maria Antonietta Crea, Ersilia Luca, Ina Ceaichisciuc, Mauro Sgreccia, Andrea Cataldo, Valter Perilli, Claudia Galletta, Papanice Domenico and Liliana Sollazzi, Department of Anesthesiology and Intensive Care Medicine, IRCCS Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy)

Chapter 5. Gastrointestinal, Hepatic, and Pancreatic Toxicity of Immune-Checkpoint Inhibitors
(Faisal S. Ali, MD, Tahan Alrifai, MD, and Sarthak Soin, MD, Department of Internal Medicine, Saint Joseph Hospital, Chicago IL, US)

Chapter 6. Vitamin E for Children: From Neonates to Adolescents
(Jaydeb Ray, Shrilaxmi Bagali and Surupa Basu, Department of Pediatric Medicine, Shri B.M. Patil Medical College, Hospital and Research Centre, Vijayapur, Karnataka, India, and others)


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