Advances in Medicine and Biology. Volume 144


Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

The opening chapter of Advances in Medicine and Biology. Volume 144 summarizes the generation of amniotic fluid, role and its clinical significance of protecting the fetus from external trauma.

Next, the role of in silico and in vitro methods are used for the prediction of cytotoxicity which is measured in terms of Selectivity Index or Therapeutic Index, which is defined as the ratio of CC50 and EC50.

Additionally the authors discuss the principles of aptamer selection and in vitro applications for bench scientists in molecular imaging, including aptahistochemistry, tissue imaging, enzyme-linked aptamer assay, aptablot, aptamer-mediated flow cytometry and mass cytometry, and super-resolution microscopy.

In order for natural rubber latex nanoparticles to be employed in tissue engineering, they need to have designed biological interaction with cells as well as favorable mechanical properties. Cells can delicately sense and respond to external nanoscale features in intricate living systems. With this in mind, chapter four demonstrates an in-depth understanding of how cell differentiation may bring a new perspective to tissue engineering including new bone regeneration and cartilage therapy.

In the penultimate chapter, a study of the relationship between the adipokine signaling dysregulation and the androgen status is proposed as necessary to develop new adipokines-based approaches to restore the steroidogenesis and spermatogenesis in male in the metabolic and endocrine diseases.

In recent stress research, coping flexibility, which is defined as an individual’s ability to modify their coping strategies effectively according to the demands of different stressful situations, has received considerable attention. The author of the closing chapter presents two cross-sectional studies in order to examine the relationship between insomnia and coping flexibility for daily stress.

Table of Contents

Table of Contents


Chapter 1. An Insight into Amniotic Fluid
(N.Tabassum, and V.Verma, Centre of Biotechnology, Nehru Science Complex, University of Allahabad, Allahabad, India, and SCRC, Department of Hematology, SGPGIMS, Lucknow, India)

Chapter 2. Role of in Silico and in Vitro Cytotoxicity Evaluation in Development of Potential Drug
(Ritika Srivastava, Farha Naaz, and Ramendra K. Singh, Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India)

Chapter 3. Aptamers in Molecular Imaging: From Principles to Biological Applications
(Sorah Yoon, PhD, and John J. Rossi, PhD, Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA)
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Chapter 4. Potential Application for Tissue Engineering in Natural Rubber Latex Nanoparticles
(Masami Okamoto, Masaya Kinoshita, and Yuki Okamoto, Advanced Polymeric Nanostructured Materials Engineering, Graduate School of Engineering, Toyota Technological Institute, Hisakata Tempaku, Nagoya, Japan)

Chapter 5. The Adipokines-Mediated Regulation of the Testosterone Production and Its Changes in Metabolic Disorders
(Alexander O. Shpakov, Vikas K. Roy, Andrey A. Bakhtyukov, and Kira V. Derkach, Department of Molecular Endocrinology and Neurochemistry, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia, and others)

Chapter 6. Insomnia, Depressive Symptoms, and Coping Flexibility
(Tsukasa Kato, Department of Social Psychology, Toyo University, Tokyo, Japan)


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