Advances in Medicine and Biology. Volume 143

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The opening chapter of Advances in Medicine and Biology. Volume 143 discusses the main indications of prophylactic oophorectomy, as well as its risks, benefits and impacts on women’s quality of life.

Additionally, the authors examine PEGylation, a chemical reaction that allows for the conjugation of a polyethylene-glycol group to another compound. Since the commercial release of adagen, the first approved PEGylated drug, PEGylation has proven to be a successful strategy for the generation of efficient drugs.

Following this, this compilation analyzes the morphological and functional disorders that may be induced by oxaliplatin. The authors present the possible side effects of this drug upon several organs, as well as the mechanisms that are activated by the nominated drug.
The authors also summarize the processes that might be occurring in Werner syndrome cells during DNA replication that then lead to the genomic instability and replication stress and, ultimately, a p38a-induced premature senescence.

The results of the authors’ studies combining the granulocyte colony-stimulating factor and enteral sorption therapy are presented in the closing chapter to ameliorate common side effects of such potent and toxic anti-cancer alkylating agents, such as melphalan.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Prophylactic Oophorectomy: Indications, Risks and Benefits
(Rosekeila Simões Nomelini, Millena Prata Jammal, Karynne Espírito Santo Benjoino, Marta Carolina Marques Sousa, and Eddie Fernando Candido Murta, Research Institute of Oncology, Department of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil)

Chapter 2. PEGylation, the Ultimate Strategy to Improve the in Vivo Efficiency of Bioactive Compounds
(Degryse Bernard, Gabriele Eden, Marco Archinti, Giuseppina Andreotti, Valentina Citro, Ronan P. Murphy, Maria Vittoria Cubellis, and Federico Furlan, School of Health & Human Performance, Dublin City University, Glasnevin, Dublin, Ireland, and others)

Chapter 3. Side Effects of Oxaliplatin: The Pathologist Point of View
(Simona Gurzu, PhD, and Ioan Jung, PhD, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, Tirgu-Mures, Romania)

Chapter 4. Premature Ageing in Werner Syndrome: A Central Role for Genomic Instability Induced-Cellular Senescence via P38α MAPK Activation?
(Terence Davis, Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK)

Chapter 5. Combination of Granulocyte Colony-Stimulating Factor and Enterosorption to Fight the Side Effects of Anti-Cancer Chemotherapy
(Shevchuk O.O., Posokhova K.A., Todor I.M., and Nikolaev V.G., I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, and R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine)

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