Advances in Medicine and Biology. Volume 136

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

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Discovered in 1961, amiodarone is a cationic amphiphilic molecule which belongs to class III antiarrhythmic drugs and therefore, it is used in the treatment of a wide range of cardiac arrhythmias. Advances in Medicine and Biology. Volume 136 begins by discussing state of the art formulations of amiodarone and outlooks for future dosage forms.

Though amiodarone hydrochloride has often been prescribed for patients with refractory or life-threatening arrhythmias, its clinical use is frequently limited because of a number of side effects such as corneal microdeposits, photosensitivity, pulmonary fibrosis, thyroid and liver dysfunction, and peripheral neuropathy. As such, the authors conduct a study wherein amiodarone hydrochloride dose-dependently induced cell death, lysosomal storage of phospholipids and neutral lipids, and oxidative stress in immortalized Schwann cells.

The following review presents scientific results and popular uses for plants from the Euphorbia genus. With nearly 2,000 species, Euphorbia is the third largest genus of blossoming plants, promptly discernable by their milky latex and particular inflorescences, called cyathia.

The laryngeal mask airway was introduced by Dr. Archie Brain in 1981 with the intent to develop a safe and effective alternative to orotracheal intubation. Since its first use in the early 90s, the laryngeal mask airway went through many structural changes and has greatly evolved. This compilation addresses this evolution and suggests that the laryngeal mask airway is a safe and easy to use device that can be considered an effective alternative to more invasive tools.

Also studied in this collection is the recent development and modern trends in the use of mesenchymal stem cells for the regeneration of damaged myocardium. Cardiovascular diseases are the main cause of death worldwide and there is no promising treatment available for cardiomyopathies except some pharmacological and surgical interventions including heart transplantation.

Obesity is associated with the chronic inflammatory condition, and a consequence of obesity is the development of cardiovascular diseases due to the presence of risk factors such as hypertension and dyslipidemia. The authors present a study is presented which analyzes recent literature data related to the link between obesity and development of cardiovascular diseases.

Following this, the authors discuss echinococcosis, a zoonotic infectious disease caused by the larval stages of four species of genus Echinococcosis, including, Echinococcus granulosus, E. multilocularis, E. oligarthrus and E. vogeli. Imaging methods for detecting space occupying lesions are the primary approaches for diagnosing of human Echinococcosis.

The clinical presentation, diagnosis and management of classical Kaposi’s sarcoma is also discussed. Classical Kaposi’s sarcoma predominantly develops in immunocompetent older males of Mediterranean or Jewish origin and is considered the most indolent of the four variants of the disease. Human herpes virus 8 is believed to be the etiological factor.

In the penultimate chapter, the authors suggest presenting experimental data in the form of hybridization energy isotherms. Theory has demonstrated a relationship between the free energy of oligo-target duplex interaction and the hybridization signal. Moreover, it has been found that target concentration changes are causing vertical shifts of hybridization energy isotherms.

Lastly, a short introduction to microphysiometry (the monitoring of energy metabolism of living cells) is given. An experiment with the mouse fibroblast cell line L929 is described, employing the intelligent mobile lab for in vitro diagnostics. The experimental conditions are described with a focus on the medium exchange and rest intervals which result in a metabolism frequency of the living cells. (Imprint: Nova Medicine and Health)

Chapter 1. Pharmaceutical Formulations of Amiodarone: Past, Present and Future
(Luciano Benedini, Javier Sartuqui and Paula Messina, Universidad Nacional del Sur, INQUISUR-CONICET, Bahía Blanca, Buenos Aires, Argentina)

Chapter 2. Pathogenetic Mechanisms of Amiodarone-Induced Peripheral Neuropathy
(Naoko Niimi, Hideji Yako, Shizuka Takaku and Kazunori Sango, Diabetic Neuropathy Project,
Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)

Chapter 3. Euphorbia: Characterization and Uses
(Luciana Puia Moro, Jéssica de Araujo Zanoni and Gustavo Orlando Bonilla-Rodriguez, ,Biosciences, Languages and Exact Sciences Institute, São Paulo State University (IBILCE-UNESP), Campus São José do Rio Preto, São Paulo, Brazil)

Chapter 4. Evolution of Airway Management in Anaesthesia: Clinical Performance of Laryngeal Mask Airway in Different Clinical Settings
(Paola Aceto, Giovanni Punzo, Valter Perilli, Antonella Tosi, Maria Antonietta Crea, Mauro Sgreccia, Andrea Cataldo, Andrea Russo, Ina Ceaichisciuc and Liliana Sollazzi, Department of Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italia)

Chapter 5. Mesenchymal Stem Cells in the Regeneration of Damaged Myocardium: Modern Research Trends and Clinical Prospects
(Muhammad Shareef Masoud, PhD, Uzair Ahmed, Muhammad Qasim, PhD, Usman Ali Ashfaq, PhD, Mahmood-ur-Rahman, PhD, and Muhammad Tariq, PhD, Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan, and others)

Chapter 6. Obesity as a Risk Factor for Cardiovascular Diseases
(Milan Obradovic, Bozidarka Zaric, Mohamed Haidara, Bratislav Stankovic and Esma R. Isenovic, Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia, and others)

Chapter 7. Laboratory Diagnosis of Human Cystic Echinococcosis
(Hossein Yousofi Darani, Department of Parasitology and Mycology, Faculty of Medicine,
Isfahan University of Medical Sciences, Isfahan, Iran)

Chapter 8. Classical Variant of Kaposi’s Sarcoma: Clinical Presentation and Therapeutic Options
(Magdalena Żychowska, MD, Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland)

Chapter 9. DNA Microarrays: Analysis of Hybridization Energy Isotherms
(Yury D. Nechipurenko, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia)

Chapter 10. Fourier Analysis in Microphysiometry
(J. Wiest, cellasys GmbH, Kronburg, Germany, and others)

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