Advances in Medicine and Biology. Volume 130

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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Advances in Medicine and Biology. Volume 130 begins by discussing proton pump inhibitors (patented in 1979) that selectively target the H,K- ATPase of gastric parietal cells as a reliable therapeutic regimen for management of acid reflux disease and gastric bleeding. Around the same time, H. pylori was recognized as the main cause of peptic ulcer. The following chapter explores how common bile duct stones can be predicted and investigated. In addition, the management of proven ductal calculi is discussed in the preoperative, intraoperative and postoperative stages. The investigation of ductal stones is partly dependent upon patient presentation and liver function tests, but also on availability of imaging modality and surgical experience. Afterwards, the authors summarize the current knowledge regarding the toxic effects of STZ on mammalian DNA and chromosomes, putting emphasis on the most recent findings on this subject.

At the chromosome level, STZ induces chromosomal aberrations (including those ones involving telomeric sequences), micronuclei and sister chromatid exchanges. A review of current state of knowledge of atmospheric parameter’s pathophysiological mechanisms and its cardiovascular risk effects is included. Additionally, some medical prevention strategies that can provide effective protection against the negative health effects of global climate change are presented. The authors go on to summarize the morphogenesis, 3D structure, and rearrangement of the IHBDs, as well as the cellular changes of cholangiocytes during development and regeneration. Recent advances based on gene targeting, lineage tracing, and three–dimensional (3D) analysis of the liver tissue have improved our understanding of the IHBDs morphogenesis and regeneration. The goal of the concluding chapter is to describe the current educational preparation and scope of practice of pediatric advance practice providers (APPs) and provide guidelines with a new practice model as to how to successfully integrate APPs into the pediatric emergency department. The pediatric health care and role of an acute care APP has evolved significantly in the last few years, with APPs seeing patients ranging from non-urgent to all kinds of pediatric emergencies.


Chapter 1. Antimicrobial Properties of PPIs
(Farideh Siavoshi, PhD and Sara Kadkhodaei, Department of Microbiology, School of Biology, University College of Sciences, University of Tehran, Tehran, Iran)

Chapter 2. Management of Common Bile Duct Stones
(James Williamson, Department of General Surgery, Weston General Hospital, Uphill, Weston-Super-Mare, Somerset, England, UK)

Chapter 3. Environmental Enrichment Protects the Retina from Ischemic and Diabetic Damage in Adult Rats
(Damián Dorfman, María F. González Fleitas, Marcos L. Aranda, Hernán H. Dieguez, Julián D. Devouassoux, Agustina Iaquinandi, Pablo H. Sande, and Ruth E. Rosenstein, Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquímica Humana, Facultad de Medicina/CEFyBO, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina, and others)

Chapter 4. Genotoxic Effects of Streptozotocin on Mammalian Cells: An Update
(Alejandro D. Bolzán, Silvina M. Richard, and Martha S. Bianchi, Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular (IMBICE, CCT-CONICET La Plata-CICPBA-UNLP), La Plata, Buenos Aires, Argentina, and others)

Chapter 5. The Global Threat of Climate Change: Implications on Cardiovascular Diseases and the Latest Knowledge Concerning Preventive Medicine
(Nora Boussoussou, MD and Melinda Boussoussou, MD, Department of Heart and Vascular Surgery, Semmelweis University, Budapest, Hungary)

Chapter 6. Development and Regeneration of Intrahepatic Bile Ducts
(Naoki Tanimizu, Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan)

Chapter 7. Emergent Allergens in Cosmetics
(Rocío Candón Morillo, Ana María Burgos Montero, and Luis Alonso González Sánchez, Allergy Department of Hospital General Mancha Centro, Alcázar de San Juan, Real, Spain

Chapter 8. A New Orientation Model for Entry Level Pediatric Advance Practice Providers in the Pediatric Emergency Department
(Shabana Yusuf, MD and Suzanne Keinhans, Section of Pediatric Emergency Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, US, and others)


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