Advances in Medicine and Biology. Volume 129


Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED106000

In this collection, the authors review novel findings strongly suggesting that YS110, a humanized monoclonal antibody with high affinity to the CD26 antigen, represents a promising novel therapy for refractory cancers, immune disorders and MERS-CoV infection. This book show that in vivo administration of YS110 inhibits tumor cell growth, migration and invasion, and enhances survival of mouse xenograft models inoculated with malignant mesothelioma (MPM), renal cell carcinoma, non-small-cell lung carcinoma, ovarian carcinoma or T-cell lymphoma via multiple mechanisms of action. Afterwards, several of the antibacterial resistance mechanisms employed by bacteria are discussed, especially those that can be targeted by novel antibacterial agents to combat resistant organisms. These mechanisms include alterations of cell wall or cell wall metabolites, mutations in antibiotic target, antibiotic deactivation by bacterial enzymes and biofilm formation. Later, the authors introduce AdRx as a treatment modality in musculo-skeletal pain, explain its rationale and techniques offering indications and contraindications for its usage. While AdRx takes its original theory from Eunice Ingham’s teaching and from followers of her teachings, this chapter confines the content to AdRx as standalone therapy in the context of musculo-skeletal pain. Near-infrared spectroscopy (NIRS) is also introduced as a non-invasive monitoring method that allows continuous real-time monitoring of cerebral hemoglobin oxygen saturation in a small area of the frontal cortex. This monitoring tool is based on the principle that some biological materials are relatively permeable to near-infrared light. In a separate study, trans-synaptic tracing from the visually responsive sites in the superior colliculus to the retina were studied using attenuated pseudorabies virus. The results demonstrated the presence of synaptic connections between the transplant and the host retina that contribute to the visual improvement observed in the superior colliculus. Continuing, in 2015, a novel pathogenesis of Crohn’s disease (the Hruska Postulate) was published. The authors aim to take what is known about Mycobacterium avium subspecies paratuberculosis, Crohn’s disease, and the Hruska Postulate and determine why Crohn’s disease is potentially curable. Several researchers have been trying to identify biomarkers that can be used for Crohn’s disease in clinical practice, however, further studies are required in order to validate most of their findings. The closing chapter introduces several diagnostic imaging techniques for kidney stone detection. A new imaging technique of C-arm tomosynthesis is described to generate volumetric information of the kidney to identify the size and location of kidney stones with limited amount of radiation dose.


Table of Contents

Table of Contents


Chapter 1. The Use of the Humanized Anti-CD26 Monoclonal Antibody YS110 as a Novel Targeted Therapy for Refractory Cancers and Immune Disorders
(Ryo Hatano, PhD, Kei Ohnuma, MD, PhD, Taketo Yamada, MD, PhD, Toshihiro Okamoto, PhD, Eriko Komiya, PhD, Haruna Otsuka, Takumi Itoh, PhD, Hiroto Yamazaki, MD, PhD, Noriaki Iwao, MD, PhD, Yutaro Kaneko, Nam H. Dang, MD, PhD, and Chikao Morimoto, MD, PhD, Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan, and others)

Chapter 2. Antibacterial Agents and Mechanisms of Bacterial Resistance
(Michael Young, Amy Stockert, PhD, and Tarek M. Mahfouz, PhD, Raabe College of Pharmacy, Ohio Northern University, Ada, OH, US)

Chapter 3. Adapted Reflextherapy: Theory and Practice to Treat Musculo-Skeletal Pain
(Gunnel A. L. Berry, Hunter’s Moon Cottage, Preston Candover, NR Basingstoke, Hampshire, England, UK)

Chapter 4. Near-Infrared Spectroscopy as a Tool to Detect Cerebral Ischemia during Carotid Surgery
(Bozidarka L Zaric, Milan Obradovic, Dragana Unic-Stojanovic, Ayman El-Menyar, Hassan Al-Thani, Djordje Radak, and Esma R Isenovic, Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia, and others)

Chapter 5. The Role of the Superior Colliculus in Studying Retinal Disease Models and Therapeutics
(Tai-Chi Lin and Biju B. Thomas, Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, US, and others)

Chapter 6. The Quest for a Cure to Crohn’s Disease
(Gilles R. G. Monif, MD, Infectious Diseases Inc., Boston University School of Medicine, Boston, MA, US, and others)

Chapter 7. Crohn’s Disease Biomarkers: What You Need to Know
(Fernando José Leopoldino Fernandes Candido, Andrey Biff Sarris, Matheo Augusto Morandi Stumpf, and Luiz Gustavo Rachid Fernandes, Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, Brazil)

Chapter 8. The C-Arm Technique for the Detection of Kidney Stones
(Nuhad A. Malalla, PhD, Ali A. Al-Azza, PhD, Jun Qin, PhD, and Ying Chen, PhD, Department of Computer Techniques Engineering, Iraq University, Basrah, Iraq)


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