Advances in Medicine and Biology. Volume 126

Leon V. Berhardt (Editor)

Series: Advances in Medicine and Biology
BISAC: MED000000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Advances in Medicine and Biology. Volume 126 opens with a discussion on fungal infections of the central nervous system and the way they have been known to parallel the incidence of systemic fungal infections in at risk populations. The reported percentages of central nervous system involvement associated with invasive fungal infections range from 3% – 100% depending on the species isolated. Next, the authors discuss the effect of agouti-related peptide on the increase of food intake and body weight in animal models of cachexia, proposing agouti-related peptide as a possible anti-anorexigenic drug. This compilation includes the first complete overview of human leukocyte antigen variation across Austronesian populations and includes the effects of admixture along the migration path during their 5,000 year diaspora.

The authors conclude that intermarriage has shifted allele frequencies in migrant peoples from those found in their original pure Austronesian stock (Taiwanese natives) towards those populations with which they have since become blended. Following this, a review of the factors affecting the photodegradation reaction and mechanism of riboflavin and related compounds is provided. Riboflavin belongs to the family of vitamin B complex and is present in a number of food products. Additionally, this book addresses the determination that the existence of the majority of microorganisms in the form of three-dimensional associates on the phase interface proves the significant survivable advantages as compare with selective ones. Afterwards, the authors present their designed dimeric dipeptide called GK-2 (bis(N-succinyl-Lglutamyl-L-lysine)hexametylendiamide) on the base of a beta-turn sequence of NGF loop4, which is most exposed to solvent and hence has a significant role in the interaction of NGF with the receptor. Later, the authors analyzed the pharmacological properties of the GlyR in the immature retina and compare those with the adult. Membranes from adult and immature rat retinas were incubated under different conditions in the presence of radioactive glycine or strychnine. Radioactive binding was considered as the specific binding to the GlyR.

The closing chapter discusses Professor Werner Kalow (1917-2008), a pioneer in the field of pharmacogenetics/pharmacogenomics, foreseeing future emerging subspecialties such as pharmacoepigenetics/pharmacoepigenomics and pharmacoanthropology. All these disciplines study human individuality and variability, paving the way for a translational personalized medicine. However, they cannot be legitimate if not properly founded by a broader, coherently unified science which deals with method and principles. (Imprint: Nova Biomedical)

Preface

Chapter 1. Fungal Brain Abscesses: A Comprehensive Review of the Epidemiology, Pathology and Treatment
(Suresh J. Antony, MD, Jennifer Misenhiemer, Leigh G. Cooper, and Hector Ramire, Texas Tech University Health Sciences Center, El Paso, TX, USA, and others)

Chapter 2. The Possible Clinical Use of Agouti-Related Peptide as a Feeding Stimulant
(Tooru M. Mizuno, Department of Physiology & Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada)

Chapter 3. The Austronesian Diaspora from an HLA Perspective
(Hisham Atan Edinur, Nur Syahmina Rasudin, Noraini Abdul Ghafar and Geoffrey Keith Chambers, Forensic Science Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia)

Chapter 4. Photochemistry of Riboflavin (Vitamin B2) and Related Compounds
(Zubair Anwar and Iqbal Ahmad, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi, Pakistan)

Chapter 5. The Main Parametabolic Complex
(Sergey V. Verevka, Prof. O.S. Kolomiychenko Institute of Otolaryngology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine)

Chapter 6. Novel Small Molecule NGF-Like Therapeutic Agent
(Sergey B. Seredenin, Polina Povarnina, and Tatyana A. Gudasheva)

Chapter 7. Glycine Expression in Adult and Immature Retina: A Pharmacological Study
(Miguel Ángel Velázquez Flores, PhD and Rocío Salceda Sacanelles, PhD, Unit of Medical Research on Human Genetics, Children’s Hospital, National Medical Center Century XXI, IMSS, Mexico City, Mexico, and others)

Chapter 8. Werner Kalow as the Father and Pioneer of Pharmacoanthropology: A Historical Approach
(Nicola Luigi Bragazzi, Khadija Aazza, Anna Siri, Tania Simona Re, Antonio Guerci, and Mariano Martini, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy

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