Advances in Medicinal Chemistry Research


Series: New Developments in Medical Research
BISAC: MED071000

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide.

Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer’s agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition.

Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material.

Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities.

Key Features

• Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery.
• Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume.
• Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today.
• Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.
(Imprint: Nova Medicine and Health)

Table of Contents

Table of Contents


Chapter 1. Anti-Obesity Drugs against Fat Absorption: Current Status and Future Prospects of Lipase Inhibitors
(Giovanni Ortiz Leoncini, PhD, Nathan Araújo de Melo, João Xavier de Araújo-Júnior, PhD, Pharmaceutical Sciences Institute, Federal University of Alagoas, Maceió, Alagoas, and others)

Chapter 2. Medicinal Chemistry of Modulation of Bacterial Resistance by Inhibition of Efflux Systems
(Pedro Gregório Vieira Aquino, PhD, Federal Rural University of Pernambuco, Garanhuns, Brazil)

Chapter 3. The Role of Thiophene Core in Medicinal Chemistry of Neglected Tropical Diseases
(Igor José dos Santos Nascimento, PhD, Paulo Fernando da Silva Santos Júnior, PhD, Rodrigo Santos Aquino de Araújo, PhD, Francisco Jaime B. Mendonça-Junior, PhD, and Thiago Mendonça de Aquino, PhD, Laboratory of Medicinal Chemistry, Federal University of Alagoas, Maceió, Brazil, and others)

Chapter 4. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer′S Agents
(Phuong-Thao Tran, PhD, and Van-Hai Hoang, PhD, Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, Hanoi, Vietnam, and others)

Chapter 5. Cancer and Computational Medicinal Chemistry: Advances and Perspectives in Drug Discovery and Design
(Rafaela Molina de Angelo, MD, Heberth de Paula, PhD, Sheila Cruz Araujo, PhD, Michell Oliveira Almeida, PhD, Simone Queiroz Pantaleão, PhD, Kathia Maria Honorio, PhD, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil, and others)

Chapter 6. Indoleamine 2,3-Dioxygenase 1 Inhibitors: Discovery, Development, and Promise in Cancer Immunotherapy
(Van-Hai Hoang and Phuong-Thao Tran, Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, Korea, and others)

Chapter 7. An Update on Eg5 Kinesin Inhibitors for the Treatment of Cancer
(Paolo Guglielmi, PhD, Daniela Secci, PhD, Giulia Rotondi, Simone Carradori, PhD, Departmento of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, P.le A. Moro 5, Rome, Italy, and others)



“This book covers hot current topics in medicinal chemistry, using a molecular-based approach, providing us with knowledge on new and valuable targets, on corresponding active synthetic and natural products, and deserves to be read by a broad audience, providing a rich food for thought.” – Dr. Marilia O. Fonseca Goulart, Professor, Federal University of Alagoas – Brazil.


Contents are addressed to who has an interest in the medicinal chemistry field. The knowledge and text inside this book are readable to anyone from Pharmacy and Medical Sciences. However, it is focused on the undergraduate and postgraduate students, as well as, professors and researchers from Universities worldwide.

Keywords: Medicinal chemistry, drug design, Alzheimer, multidrug-resistance, cancer

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