Advances in Health and Disease. Volume 70


Lowell T. Duncan (Editor)

Series: Advances in Health and Disease
BISAC: MED000000

This volume contains nine chapters that detail recent advances in health and disease. Chapter One discusses the roles and structure of hemoglobin, the iron-containing metalloprotein responsible for oxygen transport. Chapter Two analyzes the understanding that systemic inflammation underlies comorbidity in chronic obstructive pulmonary disease (COPD). Considering the many biological activities and medicinal uses of Bauhinia spp., Chapter Three presents an overview of the genus, providing an update on the botanical characteristics, chemical properties, and antimicrobial activity. Chapter Four details the pharmacokinetics of ace inhibitors and their role in diseases. Chapter Five proposes an alternative treatment of psycho-emotional disorders in limonene. Chapter Six discusses loop-mediated isothermal amplification (LAMP), a technique for the diagnosis of tuberculosis and several other bacterial, fungal, parasitic and viral infections. Chapter Seven aims to address the role and regulation of Heme Oxygenase-1 and the signaling pathways modulated by it toward gaining a comprehensive knowledge of this critical regulator of macrophage defense. Chapter Eight provides a comprehensive overview of the structure and functional insights on renin, shedding light on its role in the physiological pathways involved in blood pressure control. Lastly, Chapter Nine analyzes the studies of ceftazidime-avibactam carried out to date.

Table of Contents


Chapter 1. Hemoglobin – Its Molecular Structure and Biological Roles
Marek Graff
Institute of Nuclear Chemistry and Technology, Warsaw, Poland

Chapter 2. The Significance of Systemic Inflammation in the Pathogenesis of the Comorbid Course of Chronic Obstructive Pulmonary Disease
Stanislav Kotlyarov, PhD
Ryazan State Medical University, Ryazan, Russia

Chapter 3. The Botanical Aspects, Chemical Composition, and Antimicrobial Activity of Bauhinia spp. (Fabaceae: Cercidoideae)
Rodrigo Michelini de Oliveira Thomasi1, BS, Andreia Fonseca Silva2, MS, Jaqueline Maria Siqueira Ferreira1, PhD and Ana Hortência Fonsêca Castro1, PhD
1Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil
2Agricultural Research Company of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Chapter 4. The Pharmacokinetics of Ace Inhibitors (Perindopril) and Their Role in Diseases
Safija Herenda1, Edhem Hasković2 and Enisa Hodžić3
Department of Chemistry, Faculty of Science, University of Sarajevo, Bosnia and Herzegovina
2Department of Biology, Faculty of Science, University of Sarajevo, Bosnia and Herzegovina
3Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Chapter 5. Limonene: A Natural Anxiolytic and Antidepressant Alternative
Marcela Hernández-Ortega1, Gabriela Gutiérrez-Salmeán1,2, Regina Muñoz-Gómez3, Carla Patricia Plazola-Jacinto4 and Lourdes Valadez-Carmona5
1Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México, Lomas Anáhuac, Huixquilucan, Estado de México, México
2Centro de Especialidades del Riñón, Naucalpan, Estado de México, México
3Servicio de Apoyo Metabólico Nutricional, Hospital Regional “Adolfo López Mateos”, Ciudad de México, México
4Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México
5Centro de Investigación en Ciencias Biológicas Aplicadas, Universidad Autónoma del Estado de México, Toluca, Estado de México, México

Chapter 6. Loop-Mediated Isothermal Amplification (LAMP): Technology and Applications
with Special Reference to Tuberculosis
Priyanka Singh, MD, DNB and S. Rashmi Mudliar, PhD
All India Institute of Medical Sciences (AIIMS), Nagpur, India

Chapter 7. Heme Oxygenase 1: A Potential Drug Target with Multiple Functions
Shriya Saha1, Pijush K. Das2 and AninditaUkil1,3
1Department of Life Science and Biotechnology, Jadavpur University, Kolkata, West Bengal, India
2Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India
3Department of Biochemistry, University of Calcutta, Kolkata, West Bengal, India

Chapter 8. Renin Enzymes as Attractive Targets for Hypertension Management and Its Advancements in Drug Development and Discovery
Lakshmanan Loganathan1, Kannan Rajendran2 and Karthikeyan Muthusamy1
1Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India
2Department of General Medicine, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India

Chapter 9. Ceftazidime-Avibactam: The Microbiological Spectrum, Pharmacological Characteristics and Clinical Studies
María Cortes Avilés Martínez1 and Julián Solís García del Pozo2
Internal Medicine Department, Albacete University Hospital Complex, Albacete, Spain
2Infectious Diseases Unit, Internal Medicine Department, Albacete University Hospital Complex, Albacete, Spain


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