Advances in Health and Disease. Volume 57


Lowell T. Duncan (Editor)

Series: Advances in Health and Disease
BISAC: MED000000

This volume includes ten chapters that present recent research advances in health and disease. Chapter One reviews the importance of 5alpha-reductase inhibitors, with focus on oxidized steroidal derivatives, for treatment of prostatic diseases. Chapter Two examines inflammation in chronic obstructive pulmonary disease. Chapter Three indicates plausible mechanistic insights of binding of vitamin B12 and its precursor cobinamide. Chapter Four summarizes fluid therapy for treatment of traumatic brain injury. Chapter Five explores the healthcare response to COVID-19 in Bhutan and Nepal. Chapter Six examines changes in immune function associated with aging. Chapter Seven discusses the epidemiology, clinical features, investigations, and management of pyogenic spondylodiscitis.

Table of Contents


Chapter 1. Oxidized Steroids as 5α-Reductase Inhibitors with Potential Interest in Prostatic Diseases: A Review
V. Brito, G. Alves, P. Almeida and S. Silvestre
Health Sciences Research Center, University of Beira Interior, Covilhã, Portugal

Chapter 2. NLRP3 Inflammasome-Assisted Pathogenesis in Chronic Obstructive Pulmonary Disorder
Sushweta Mahalanobish, Noyel Ghosh and Parames C. Sil
Division of Molecular Medicine, Bose Institute, Calcutta, West Bengal, India

Chapter 3. Structural Insights of Cobalamin and Cobinamide Uptake by ABC Importer of Vibrio Species
Arunima Bhattacharya1, Samriddhi Bhattacharya1, Shubhangi Agarwal1,2 and Jhimli Dasgupta1
Post Graduate Department of Biotechnology, St. Xavier’s College (Autonomous), Kolkata, West Bengal, India
2Weill Cornell Medicine, Department of Anesthesiology, New York, USA

Chapter 4. The Role of Fluid Therapy in Traumatic Brain Injury
Eduardo Esteban-Zubero1, PhD, Cristina García-Muro2, MD and Moisés Alejandro Alatorre-Jiménez3, PhD
1Emergency Department, Hospital San Pedro, Logroño, Spain
2Department of Pediatrics, Hospital San Pedro, Logroño, Spain
3Department of Pediatric Gastroenterology, Children’s Mercy Hospital, Kansas City, USA

Chapter 5. Effectiveness of the Healthcare Delivery Systems in Prioritizing COVID-19: Case Studies of Bhutan and Nepal
Chu Qian, MPH
Weatherhead East Asian Institute, Columbia University, NYC, USA

Chapter 6. Immune Function Is Depressed with Aging While Inflammation Is Heightened: An Enigma
Stephen C. Bondy1 and Meixia Wu2
Department of Occupational and Environmental Health and Department of Medicine, University of California, Irvine, Irvine, CA, USA
2Evergreen World ADHC, Westminster, CA, USA

Chapter 7. Pyogenic Spondylodiscitis
Dr. Balaji Zacharia1 and Dr. Afsal Valiyaparambil2
Professor, Department of Orthopedics, Government Medical College, Kozhikode, Kerala, India
2Senior Resident, Department of Orthopedics, Government Medical College, Kozhikode, Kerala, India

Chapter 8. Characterization of Vitamin B12 Compounds in Foods
K. Koseki, T. Bito, PhD and F. Watanabe, PhD
The United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan

Chapter 9. Tryptophan: An Amino Acid to Manage Biofilm Threat Efficiently
Payel Paul1, Sridebesh Ghorui2, Poulomi Chakraborty1, Sharmistha Das1, Prosun Tribedi1 and Debabrata Ghosh Dastidar2
Department of Biotechnology, The Neotia University, West Bengal, India
2Guru Nanak Institute of Pharmaceutical Science and Technology, West Bengal, India

Chapter 10. Nrf2 as One of the Potential Targets in Multiple Sclerosis
Samira Shirooie, PhD
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


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