Advances in Experimental Surgery. Volume 2

Huifang Chen, M.D., Ph.D. (Editor)
Department of Surgery, Faculty of Medicine, Research Center, CHUM, Notre-Dame Hospital, CHUM, University of Montreal, Montreal, Canada

Paulo N. Martins, M.D., Ph.D. (Editor)
University of Massachusetts, UMass Memorial Medical Center, Department of Surgery, Transplant Division, Worcester, MA, US

Series: Surgery – Procedures, Complications, and Results
BISAC: MED085000

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Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery.

The present book covers wide experimental surgery in preclinical research models subdivided in two volumes. Volume I introduces surgical basic notions, techniques, and different surgical models involved in basic experimental surgery and review the biomechanical models, ischemia/reperfusion injury models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models. The second volume also introduces graft-versus-host disease, and other experimental models. Review the advances and development of recent techniques such as tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. The book documents the enormous volume of knowledge we have acquired in the field of experimental surgery.

In this book, we have invited experts from the United States, Canada, France, Germany, China, Japan, Korea, UK, Sweden, Netherland, Hungary and Turkey to contribute 36 chapters in the fields of their expertise. These two volumes are the compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.

Preface

Chapter 1. Laparoscopic Experimental Surgery Models
(Natalie Bath, MD, Demetrius Litwin, MD, Paulo N. Martins, MD, PhD, Department of Surgery, UMass Memorial Medical Center, University Campus, Worcester, MA, and others)

Chapter 2. Experimental Models of Sepsis
(Norbert Nemeth, MD, PhD, Mihai Oltean MD, PhD, and Bela Fulesdi MD, PhD, Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and others)

Chapter 3. Bariatric Experimental Surgery Models
(Osman Bilgin Gulcicek, MD, Istanbul Bagcilar Training and Research Hospital, Department of General Surgery, Istanbul, Turkey)

Chapter 4. Animal Models of Heart Failure
(Mouer Wang, MD, Cardiovascular Institute, Stanford University, Stanford, California, USA)

Chapter 5. Hepatopancreatobiliary Surgery Experimental Models
(Paulo N. Martins, MD, PhD, Natalie Bath, MD, Adel Bozorgzadeh, MD, Department of Surgery, Division of Organ Transplantation, UMass Memorial Medical Center, University Campus, Worcester, MA)

Chapter 6. Animal Models of Acute Graft-Versus-Host and Host-Versus-Graft Responses and Diseases
(Abraham Matar and Raimon Duran-Struuck, Department of Surgery, Emory University School of Medicine, Atlanta, GA, and others)

Chapter 7. Microfluidic Devices and Micro-Dissected Tissue to Predict Therapeutic Response in Patients with Prostate Cancer
(Robin Guay-Lord, Muhammed Abdul Lateef, PhD, Kayla Simeone, Benjamin Péant, PhD, Jennifer Kendall-Dupont, Anne-Marie Mes-Masson, PhD, Thomas Gervais, PhD, and Fred Saad, MD, Department of Molecular Biology, Surgery and Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada)

Chapter 8. Of Mice and Rats: Animal Models for Use in Laparoscopy and Laparotomy with Human Ovarian Cancer Cell Line Intraperitoneal Xenografts
(Philippe Sauthier, MD, Anne-Marie Mes-Masson, PhD, Louise Champoux, Michèle Bally, PhD, Diane M. Provencher, MD, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, Canada)

Chapter 9. Organ Bioengineering through Decellularization and Recellularization Approaches
(Maria Jaramillo, PhD, Basak E. Uygun, PhD, Center for Engineering in Medicine, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, US)

Chapter 10. Wound Healing and Scarring
(A. Samandar Dowlatshahi, MD, Plastic and Reconstructive Surgery, Harvard Medical School, Boston, MA)

Chapter 11. Organ Preservation
(Cheng Yang MD, PhD, Jiawei Li MD, Ruiming Rong MD, PhD, Department of Urology, Zhongshan Hospital, Fudan University; Shanghai Key Laboratory of Organ Transplantation; Shanghai, China, and others)

Chapter 12. Machine Organ Preservation
(Hazel L. Marecki, Isabel Brüggenwirth, Paulo N. Martins, MD, PhD, Department of Surgery, Division of Organ Transplantation, University of Massachusetts Medical School, Worcester, Massachusetts, US)

Chapter 13. Microcirculation
(Norbert Nemeth, MD, PhD, and Andrea Szabo MD, PhD, Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)

Chapter 14. Experimental Gene Therapy Using Naked DNA
(Eiji Kobayashi MD, PhD, Department of Organ Fabrication, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan)

Chapter 15. Robotic Surgery in Experimental Medicine
(Sandra S.Y. Kim, David Ian Harriman, MD, and Christopher Nguan, MD, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia)

Index

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