Advances in Experimental Surgery. Volume 1

Huifang Chen, M.D., Ph.D. (Editor)
Department of Surgery, Faculty of Medicine, Research Center, CHUM, Notre-Dame Hospital, CHUM, University of Montreal, Montreal, Canada

Paulo N. Martins, M.D., Ph.D. (Editor)
University of Massachusetts, UMass Memorial Medical Center, Department of Surgery, Transplant Division, Worcester, MA, US

Series: Surgery – Procedures, Complications, and Results
BISAC: MED085000

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Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery.

The present book covers wide experimental surgery in preclinical research models subdivided in two volumes. Volume I introduces surgical basic notions, techniques, and different surgical models involved in basic experimental surgery and review the biomechanical models, ischemia/reperfusion injury models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models. The second volume also introduces graft-versus-host disease, and other experimental models. Review the advances and development of recent techniques such as tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. The book documents the enormous volume of knowledge we have acquired in the field of experimental surgery.

In this book, we have invited experts from the United States, Canada, France, Germany, China, Japan, Korea, UK, Sweden, Netherland, Hungary and Turkey to contribute 36 chapters in the fields of their expertise. These two volumes are the compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.

Preface

Chapter 1. History, Development and the Importance of Experimental Surgery
(Huifang Chen, MD, PhD, Pierre Daloze, MD, Laboratory of Experimental Surgery, Department of Surgery CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 2. The Discovery, Development and Patent Protection of New Drugs in Experimental and Clinical Research
(Anlun Ma, Laboratory of Experimental Surgery, Department of Surgery, University of Montreal, Montreal, Quebec, Canada)

Chapter 3. Ethical, Legal and Educational Issues in Experimental Surgery
(Kupa Bilolo, MD, Laboratory of Experimental Surgery, Department of Surgery, Center of Research of Montreal University (CR-CHUM), University of Montreal, Montreal, Quebec, Canada)

Chapter 4. Veterinary Care and Management of Rodent and Large Animal Models in Transplantation Research
(Patrick Lester, James Marx, Portia S. Allen, Bram V. Lutton, and Raimon Duran-Struuck, Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, US, and others)

Chapter 5. Pre-Operative and Postoperative Care in Experimental Surgery
(Yanxin Hu, MD, Laboratory of Experimental Surgery, Department of Surgery, CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 6. Fluid, Electrolytes, and Acid-Base Balance in Experimental Surgery
(Kupa Bilolo, MD, Laboratory of Experimental Surgery, Department of Surgery, Research Center of Montreal University (CR-CHUM), University of Montreal, Montreal, Quebec, Canada)

Chapter 7. Imagery Techniques in Experimental Surgery
(Junzheng Peng, MD, PhD, and Huifang Chen, MD, PhD, Cardiovascular Phenotyping Core Facility CRCHUM, University of Montreal, Montreal, Quebec, Canada, and others)

Chapter 8. Telemetry Applications in Experimental Animals for Studying Human Diseases
(Junzheng Peng, MD, PhD, and Huifang Chen, MD, PhD, Cardiovascular Phenotyping Core Facility CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 9. Small Animals as Experimental Models
(Rebekah Wilson MD, Adrien Kissenpfennig, PhD, James McDaid MD, PhD, Dept. Transplant Surgery, City Hospital, Belfast, UK, and others)

Chapter 10. Large and Translational Animal Models in Experimental Surgery
(Kupa Bilolo, MD, Laboratory of Experimental Surgery, Department of Surgery, Center of Research of Montreal University (CR-CHUM), University of Montreal, Montreal, Quebec, Canada)

Chapter 11. Cardiovascular Biomechanical Models
(Ethan Kung, PhD, Cardiovascular Modeling & Experimentation Research Laboratory, Department of Mechanical Engineering, Department of Bioengineering, Clemson University, SC, US)

Chapter 12. Isolated Kidney Perfusion Models
(Isabel Brüggenwirth, Henri G.D. Leuvenink, Paulo N. Martins, MD, PhD, Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, and others)

Chapter 13. Isolated Liver Perfusion Systems
(Isabel Brüggenwirth, Hazel Marecki and Paulo N. Martins, MD, PhD, Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, and others)

Chapter 14. Experimental Models of Cartilage Repair
(Jakub Zafar Qazi, Huifang Chen, MD, PhD, and Muhammad Zafarullah, PhD, Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada)

Chapter 15. Experimental Models of Fracture Repair
(Jakub Zafar Qazi, Huifang Chen, MD, PhD, and Muhammad Zafarullah, PhD, Anatomy and Cell Biology Program, McGill University, Montreal, Quebec)

Chapter 16. Experimental Solid Organ Transplantation in Small Animals
(Hao Dun, MD, Laboratory of Experimental Surgery, Department of urgery CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 17. Large Animal Models in Organ Transplantation
(Babak Movahedi MD, PhD, Maria Lucia Madariaga, MD, Sebastian Michel, MD, Adel Bozorgzadeh, MD, Paulo N. Martins MD, PhD, Division of Organ Transplantation, Department of Surgery, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, US)

Chapter 18. Experimental Composite Tissues and Soft Tissues Transplantation
(Hao Wang, MD, PhD, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin General Surgery Institute, Tianjin, China)

Chapter 19. Ischemia-Reperfusion Injury Animal Models
(Junzheng Peng, MD, PhD, and Huifang Chen, MD, PhD, Cardiovascular Phenotyping Core Facility CRCHUM, University of Montreal, Montreal, Quebec, Canada)

Chapter 20. Encapsulated Islet Transplantation: From Allogeneic to Xenogeneic Transplantation
(Kun Ho Yoon, MD, PhD, Eun Young Lee, MD, PhD, Jun-Seop Shin, PhD, Byoung-Hoon Min, PhD, Jong-Min Kim, PhD, and Chung-Gyu Park, MD, PhD, Division of Endocrinology and Metabolism, Department of Internal Medicine, Soul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and others)

Chapter 21. Hepatocyte Transplantation
(Nalu Navarro Alvarez, MD, PhD, and Paulo Martins, MD, PhD, Center for Transplantation Sciences (CTS), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts)

Index

“The current book presents extensive experimental surgery in preclinical research models subdivided into two volumes. Volume I introduces surgical basic notions, technique, and different surgical models involved in basic experimental surgery and a review of the biomechanical models, ischemia/reperfusion models, repair and regeneration models, and organ and tissue transplantation models, respectively. Volume II introduces several specific experimental models such as laparoscopic and bariatric experimental surgical models, graft-versus-host disease, tissue engineering, organ preservation, wound healing and scarring, gene therapy and robotic surgery. I congratulate the authors in producing two admirable volumes in experimental surgery.” - Prof. Xian C. Li, M.D., Ph.D., Cornell University, New York, USA

"Experimental surgery is a key link for the development in clinical surgery, research and teaching. In recent 20 years, experimental surgery has achieved new advances like laparoscopic and robotic surgery, tissue engineering and gene therapy. The book covers enormous volume of knowledge which will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery." - Prof. S. Stepkowski, PhD. Toledo University, USA

"This book of two volumes is a compilation of basic experimental surgery and updated advances of new development in this field that will be invaluable for any experimental laboratory. This book is well-written, comprehensive, and worth reading. For everybody working in this field or interested in experimental surgery, these volumes will be essential additions on their book shelf." - Prof. Antonio Di Cataldo, MD., University of Catania, Italy

"In this book, editors invited specialists from 12 countries to contribute 36 chapters in the fields of their expertise. These two volumes cover advanced experimental surgical procedures and innovations in this field. The readers of this book can apply these procedures to, not only develop increasingly practical techniques, but also to apply these new issues to biomedical research. I applaud the authors in producing a praiseworthy book." - Prof. Louis Dumont, PhD., University of Montreal, Canada

"Advances in Experimental Surgery is a very valuable and multifaceted review of the contributions of the experimental laboratory to the progress in clinic. These two volumes involve experimental surgery, describe recent advances in experimental surgery of preclinical research and clinical practice. It is an excellent reference book to train young generations of medical scientists in surgery." - Prof. Pierre Daloze, MD., FRCSC., University of Montreal, Canada

The book covers enormous volume of knowledge which will be invaluable to surgeons, residents, graduate students, surgical researchers, physicians, immunologists, veterinarians and nurses in surgery.
It is also helpful for pharmacologists working in industries

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