Advances in Drug Testing and Drug Delivery Systems

Kin Fong Lei, Ph.D.
Graduate Institute of Medical Mechatronics, Department of Mechanical Engineering, Chang Gung University, Taiwan

I-Chi Lee
Chang Gung University, Taiwan

Yi-Chen Li
Institute of Biomedical Engineering, National Taiwan University, Taiwan

Series: Substance Abuse Assessment, Interventions and Treatment
BISAC: PSY038000

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In the past century, numerous drugs have been developed and have helped us to get rid of various diseases. By the mature development of micro/nano technologies, precise, predictable, and well-controlled instruments and tools for drug testing and delivery have been suggested. Efficient drug development and effective drug delivery can benefit the quality of human lives.

This book presents advances in drug testing and drug delivery. It covers a board spectrum of topics and state of the art research in this field. As such, the book is divided into three parts, comprised of nine chapters. The first part (Chapter One) introduces recent developments of drug testing technologies targeting for subjects who suffer from drug abuse and addiction. Specimens of oral fluid and hair are the focuses of this discussion. The second part (Chapters Four through Six ) includes the advanced technologies for drug testing. In the development of a new drug, the process is lengthy and costly. There are a large amount of drug tests on living cell culture involved. Therefore, in order to decrease the development time and increase the prediction precision of the drug effectiveness, advanced technologies of 3D cell culture and microfluidics for drug testing are introduced. The third part (Chapters Seven to Nine) presents the novel drug delivery systems. Compared to conventional oral and parenteral administration, microneedle patches and polymer delivery carriers are novel drug delivery approaches. In-depth discussions of different delivery systems are included to achieve promising therapeutic effects. These novel and ongoing techniques provide new insights and possibilities for drug testing and drug delivery. The reader will gain a unique perspective on the challenges and emerging opportunities in this exciting field. (Imprint: Nova)

Preface

Chapter 1. Introduction to Drug Testing - Oral-Fluid and Hair Drug Testing

Chapter 2. Three Dimensional Culture and Drug Testing

Chapter 3. Cancer Stem Cells, Drug Testing, and Therapeutic Strategies

Chapter 4. Microfluidics Technology for Drug Testing

Chapter 5. Real-time Cell-based Assays

Chapter 6. Organs on Chips

Chapter 7. Novel Transdermal Delivery System - Microneedle Patches

Chapter 8. Novel Polymer Delivery Carrier I - Thermal- and pH- Sensitive Polymer

Chapter 9. Novel Polymer Delivery Carrier II - Photo- and Electric- Sensitive Polymer

About the Authors

Index

Audience: Academic scientists and engineers related to the biotechnology development.

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