Advances in Chemistry Research. Volume 85


James C. Taylor (Editor)

Series: Advances in Chemistry Research
BISAC: SCI013000

This book discusses the latest advances in chemistry research. Chapter 1 summarizes the current state of C-scorpionate coordination chemistry, exploring the synthesis of their metal complexes and the exciting array of applications that these compounds have unlocked. Chapter 2 discusses the charge-transfer (CT) reactivity in A(acid)B(base) systems and how it is approached in both the gas-phase and on catalytic surface. Chapter 3 covers information on fundamental knowledge on ligand-protein interaction and how it can be utilized to design a variety of new aggregation inhibitors and anti-amyloid therapeutics. Chapter 4 introduces the successful drug discovery process that includes not only optimization of drug-biological receptor interactions but also efficient delivery to the site of action by means of crossing biomembranes. Chapter 5 discusses how drugs on the pharmaceutical market use hydrophobic poorly soluble substances to successfully distribute into the body. Chapter 6 is aimed at determining the influence of coal charge grindability on the scheme of preparing coal for coking by optimizing the operation of the crushing department.

Table of Contents

Chapter 1. The Exciting Coordination Chemistry of C-Scorpionate Compounds
Luísa M. D. R. S. Martins
Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Engenahria Química, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

Chapter 2. Catalytic Activity in Charge-Transfer Systems
Roman F. Nalewajski
Department of Theoretical Chemistry, Jagiellonian University, Cracow, Poland

Chapter 3. Hydrophobic/Lipophilic Properties of Drugs Demonstrated by Partition/Distribution Coefficients at Different pH and Temperatures: Relation to Solubility and Permeability
Tatyana V. Volkova and Olga R. Simonova
Department of Physical Chemistry of Drugs, G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences Ivanovo, Russia

Chapter 4. Modulations of Partition/Distribution Coefficients with Cyclodextrins Exemplified by Drug Compounds of Different Hydrophobicity
Tatyana V. Volkova
Department of Physical Chemistry of Drugs, G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences Ivanovo, Russia

Chapter 5. Determination of Mechanical Strength of Coal and Coal Charges
Valentine Koval¹, PhD, Denis Miroshnichenko², Olena Bogoyavlenska²
1State Enterprise, Ukrainian State Research Institute for Carbochemistry (UKHIN), Coal Department, Kharkiv, Ukraine , 2National Technical University, Kharkiv Polytechnic Institute, Department of Oil, Gas and Solid Fuel Processing Technology, Kharkiv, Ukraine

Chapter 6. Insight into Protein–Ligand Interaction: The Effect on Protein Aggregation
Aurica Precupas, PhD and Vlad Tudor Popa, PhD
Romanian Academy, “Ilie Murgulescu” Institute of Physical Chemistry, Bucharest, Romania

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