Advances and Challenges in Stroke

Michelangelo Mancuso and Ubaldo Bonuccelli (Editors)
Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa and Azienda Ospedaliera Universitaria Pisana, Italy

Series: Neuroscience Research Progress
BISAC: MED010000

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Stroke, a brusque interruption of blood supply in an area of the brain, has a sudden and frequently devastating impact on both patients and their families. Although stroke is most common in older people, it can occur in individuals of any age, including young adults and children.

Fortunately, the prospects for preventing and treating stroke are far better than they were just a few decades ago. However, a lot of challenges await physicians and researchers in terms of prevention, pathogenesis and treatment. Stroke remains a high priority medical condition for our society; globally, about 15 million people suffer of cerebrovascular diseases, with stroke being the most frequent life-threatening neurological disease and the third cause of death and disability.

The authors of Advances and Challenges in Stroke hope to guide readers through the complexity of stroke pathogenesis, from the molecular basis to the most recent advances in terms of pathophysiological cascade leading to cell death. Through the expert opinion of Italian and European researchers, multiple aspects will be explored, including the etiology of juvenile or cryptogenic stroke, correlations between the heart and brain, state-of-the-art telemedicine in reducing door to needle and decision-making time, and the contribution of modern neuroimaging techniques and surgical/endovascular treatment in the hyperacute stroke phase.
(Imprint: Nova Biomedical)

Preface

Chapter 1. Monogenic Diseases Associated with Stroke
V. Montano, N. Giannini, M. Maccarrone, C. Simoncini, E. Ferrari, L. Ulivi, G. Siciliano, U. Bonuccelli and M. Mancuso (Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa, Pisa, Italy)

Chapter 2. Fabry Disease: An Introduction for Neurologists
Atul B. Mehta (Professor of Haematology, Royal Free Hospital, University College London School of Medicine, London, UK)

Chapter 3. Pathogenesis of Hemorragic Stroke
A. Bersano (Cerebrovascular Diseases Unit, C. Besta Neurological Institute, Milan, Italy)

Chapter 4. Animal Models of Stroke: Present and Future
B. Casolla, S. Candela, A. Ciacciarelli and F. Orzi (NESMOS (Neurosciences, Mental Health and Sensory Organs) Department, University “Sapienza”of Rome, Italy)

Chapter 5. The Added Value of Neurosonology: A Tax-Free Genius in the Probe
Chiti A. and Del Sette M. (Neurology Unit, Ospedale Sant’Andrea, La Spezia, Italy, and others)

Chapter 6. Intravenous Thrombolysis: Present Evidences and Future Perspectives
Danilo Toni and Alessio Pieroni (Emergency Department Stroke Unit, Hospital Policlinico Umberto I, Department of Neurology and Psychiatry, ‘Sapienza’ University, Rome, Italy)

Chapter 7. Haemorrhage: Emerging Therapies
Valentina Arnao and Maurizio Paciaroni (Biomedical Department of Internal and Specialistic Medicine (Di.Bi.M.I.S), University of Palermo, Palermo, Italy, and others)

Chapter 8. Management of Intracranial Stenosis
Valentina Arnao and Maurizio Paciaroni,PhD (School of: Medicina Clinica e Scienze del Comportamento-Biomedical Department of Internal and Specialistic Medicine (Di.Bi.M.I.S), University of Palermo, Palermo, Italy, and others)

Chapter 9. "Telestroke”, a Frontier in the Globalization Era
C. M. Klingner, O. W. Witte and A. Günther (Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany)

Chapter 10. Imaging in Acute Stroke
Mirco Cosottini and Graziella Donatelli (Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy)

Chapter 11. Stroke and Atrial Fibrillation
E. Soldati, F Menichetti and MG Bongiorni (Second Cardiology Unit, Arrhythmology, Cardio-thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy)

Chapter 12. Subclinical Atrial Fibrillation (SCAF) and Embolic Stroke of Undetermined Source (ESUS)
Alberto Chiti (Neurology Unit, Ospedale Sant’Andrea, La Spezia, Italy)

Chapter 13. Direct Oral Anticoagulants in Patients with Atrial Fibrillation
Isabella Canavero and Giuseppe Micieli (Department of Emergency Neurology, Cerebrovascular Disease and Stroke Unit, IRCCS National Neurologic Institute Foundation “Casimiro Mondino,” Pavia, Italy)

Chapter 14. Emerging Biochemical Risk Markers of Stroke
M. Franzini1, M. Emdin and A. Paolicchi (Dip. di Ricerca Traslazionale e Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Italy, and others)

Chapter 15. Mitochondria, Mitochondrial DNA and Stroke
M. Maccarrone, E. Caldarazzo Ienco, N. Giannini, V. Montano, A. Lo Gerfo, D. Orsucci, U. Bonuccelli, M. Mancuso and G. Siciliano, Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa, Pisa PI, Italy)

Chapter 16. Cervical Artery Dissection: What’s New in 2015
Stéphanie Debette (Department of Neurology, Bordeaux University Hospital, Bordeaux, France, and others)

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