Advanced Glycation End-Products: Sources and Effects

Patrik Bast (Editor)

Series: Biochemistry and Molecular Biology in the Post Genomic Era
BISAC: SCI007000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Advanced Glycation End-Products: Sources and Effects attempts to describe the role of advanced glycation end-products, particularly dietary advanced glycation end-products, in the pathological expansion of adipose tissue as well as their implications in the development of obesity associated complications.

The effects of advanced glycation end-products on vasculature and their pathological implications are also described, focusing on the epigenetic mechanisms (particularly that of miRNA) modulating their effects.

The authors summarize the information available on the impact of hyperglycemia on the influencing factors of non-enzymatic glycosylation, the formation of advanced glycation end-products, and the role of advanced glycation end-products and their specific receptors in diabetes.

The role of advanced glycation end-products to diabetic complications is examined in conjunction with the protective role of the endogenous secretory receptor for advanced glycation end-products (esRAGE) and the therapeutic interveentions that would mimic esRAGE activity.

In closing, poly-L-lysine modified with advanced glycation end-products is prepared and used as an antigen to generate a single-chain fragment variable monoclonal antibody (scFv mAb) through phage display technology.
(Imprint: Nova)

Preface

Chapter 1. Advanced Glycation End-Products and Adipose Tissue Dysfunction
(Manu Sudhakar, Department of Human Genetics, Sri Ramachandra Medical College and Research Institute, Chennai, India)

Chapter 2. Advanced Glycation End Products and Their Effects on Vascular Cell Function-Modulation by miRNAs
(S. Manju Devi and P. R. Sudhakaran, Department of Biochemistry,Bhavan’s Vivekananda College, Sainikpuri, Secunderabad, India, and others)

Chapter 3. Glycation, Advanced Glycation End Products and Diabetes
(Haixia Chen and Yue Chen, Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China)

Chapter 4. Role of Endogenous Secretory Receptor for Advanced Glycation End Product in Diabetes Mellitus and Its Complications
(R. Vimalavathini and S. H. R Subhashri, Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India, and others)

Chapter 5. Protective Role of Salinity against the Accumulation of Advanced Glycation end Products in Embryogenic Suspension Cultures of Dactylis Glomerata L.
(Eva Popova, Lyuben Zagorchev, Rositsa Tsekovska, Roumyana Mironova and Mariela Odjakova, Sofia University ″St. Kl. Ohridski″, Faculty of Biology, Department of Biochemistry, Sofia, Bulgaria, and others)

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