Adrenal Glands: From Pathophysiology to Clinical Evidence

Gaetano Santulli, MD, PhD (Editor)
Columbia University Medical Center, College of Physicians & Surgeons, Columbia University, New York, NY, USA

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

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The present book provides a state-of-the-art overview of the adrenal gland pathophysiology. It covers both up-to-date basic and clinical notions on adrenal glands. Amidst the molecular aspects, discussed by leading scientists in the field, there are ER stress, microRNA, hormone biosynthesis, and interactions with other organs. Clinical insights for students and physicians are also provided, from the imaging to the therapeutic management of common disorders of the gland, including adrenal failure, hyperaldosteronism, Cushing’s syndrome, neurologic disease, and cancer both in adults and pediatric patients.

As mentioned above, chapter contributions are made by worldwide renowned experts, scientists and physicians, working in prestigious hospitals and universities including Brown, Oxford, Case Western Reserve University, Cleveland Clinic, Chinese University of Honk Kong, University of Tennessee, Indiana University School of Medicine, Monash Health in Clayton, Australia, University of Calgary, Northern Ontario School of Medicine and Laurentian University, Medical University of Gdańsk, Université Pierre et Marie Curie in Paris, France, University of Minho, Braga, Portugal, St. Vincent’s University Hospital in Dublin, Universities of Londrina, Alfenas, Sao Paulo, and Rio de Janeiro, Brazil. Throughout these chapters, the authors spotlight future avenues for research in basic pathophysiology and in therapy/prevention, in addition to thorough overviews of the current literature pertaining to the adrenal gland and its functional roles. The book also includes several color photographs, schemes and diagrams of molecular relationships, and tables that support and complement the text.

The comprehensive and systematic overview provided within this book is expected to assist the reader in comprehending the importance of taking into account the functional roles of the adrenal gland and also to address questions and unresolved issues regarding the treatment of its disorders. Finally, the editor would like to express his sincere appreciation to all the contributors for their dedicated collaboration in this project. He would also like to thank Ms. Carra Feagaiga for her patient support. He sincerely hopes this book will enable readers to connect basic research principles with up-to-date clinical knowledge, thereby encouraging future discoveries and developments of new therapeutic strategies to treat disorders of the adrenal gland.

(Imprint: Nova Biomedical)

Preface

1) Imaging of Adrenal Gland
(Michelle Tsang Mui Chung, and Julie H. Song, Department of Diagnostic Imaging, Rhode Island Hospital, Alpert School of Medicine, Brown University, Providence, RI, USA)

2) Mechanisms Integrating Endoplasmic Reticulum Stress, Cholesterol Metabolism and Steroid Hormone Biosynthesis in the Adrenal Cortex
(Zhi-qiang Pan, Yi-yi Zhang, Vivek Choudhary, and Wendy B. Bollag, Shanghai University of Traditional Chinese Medicine, Shanghai, China and Medical College of Georgia at Georgia Regents University, Augusta, GA, USA)

3) Regulation of Catecholamine Production from the Adrenal Medulla
(Anastasios Lymperopoulos, Smit Chowdhary, Kamarena Sankar, and Isis Simon, Nova Southeastern University College of Pharmacy, Ft. Lauderdale, FL, USA)

4) Interactions of the Adrenal Glands with Adipose Tissue
(Janella León, and Atil Y. Kargi, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA)

5) Hypoadrenalism: Primary and Secondary Adrenal Failure
(Marianna Minnetti and Ashley B. Grossman, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK)

6) Clinical Management of Hyperaldosteronism
(Jun Yang and Peter J. Fuller, MIMR-PHI Institute of Medical Research, and Department of Endocrinology, Monash Health, Clayton, Australia)

7) Cushing’s Syndrome
(Georgiana Alina Dobri, Divya Yogi-Morren, and Betul A. Hatipoglu, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA)

8) Pheocromocytomas and Paragangliomas
(Anna Heeney, Aoife J. Lowry, Rachel K. Crowley, and Ruth S. Prichard, St. Vincent’s University Hospital, Dublin, Ireland)

9) New Insights of Glucocorticoids Actions on the Homeostatic Control of Energy Balance and Stress-related Responses
Ernane Torres Uchoa, PhD, Silvia Graciela Ruginsk, PhD, Rodrigo Cesar Rorato, PhD, Beatriz de Carvalho Borges, PhD, (Jose Antunes-Rodrigues, and Lucila Leico K. Elias, State University of Londrina, Londrina, PR; Federal University of Alfenas, Alfenas, MG; University of Sao Paulo, Ribeirao Preto, SP, Brazil)

10) Role of Adrenal Hormones in the Fetal Programming of Hypertension
(Sandhya Khurana, Collin J. Byrne, Stephanie Mercier, Jeremy Lamothe, Chad R. Williamson, Julie Grandbois, and T.C. Tai, Northern Ontario School of Medicine and Laurentian University, Canada)

11) Adrenal Cortical Neoplasms: Perspectives in Pediatric Patients
(Shahrazad T. Saab, and Gregory T. MacLennan, Case Western Reserve University, Cleveland, OH, USA)

12) Premature Adrenarche
(Alexander K. C. Leung, Kam Lun Hon, and Benjamin Barankin, The University of Calgary, Canada; Toronto Dermatology Centre, Toronto, Ontario, Canada and Chinese University of Hong Kong, Shatin, Hong Kong, China)

13) Hyperandrogenism of Adrenal Origin
(Dominik Rachoñ, Department of Clinical and Experimental Endocrinology, Medical University of Gdañsk, Poland)

14) Functional Roles of Corticosterone and Stress in Penile Morphology
(Diogo B. De Souza, Dilson Silva, Célia M. Cortez, Waldemar S. Costa, Francisco J.B. Sampaio, Urogenital Research Unit, State University of Rio de Janeiro, Brazil)

15) Glucocorticoids and Neurodegeneration
(Sheela Vyas, Ana Joao Rodrigues, Joana Margarita Silva, Francois Tronche, Nuno Sousa, and Ioannis Sotiropoulos, Université Pierre et Marie Curie Paris, France; University of Minho, Braga, Portugal)

16) Disorders of the Adrenal Glands: The Neurologists’ Point of View
(Tulio Bertorini, and Lihong Shen, Department Of Neurology and Neurophysiology, University of Tennessee, Health Science Center, Memphis, TN, USA)

17) Adrenocortical Cancer
(Amudhan Pugalenthi, and Eren Berber, Cleveland Clinic, Cleveland, OH, USA)

18) Adrenal Leiomyomas
(Prashant B. Joshi, Sir HN Reliance Foundation Hospital & Research Centre, Mumbai, India)

19) Rare Tumors of the Adrenal Gland
(Shahrazad T. Saab, Liang Cheng, and Gregory T. MacLennan, Case Western Reserve University, Cleveland, OH and Indiana University School of Medicine, Indianapolis, IN, USA)

Index

Audience: Medical students and physicians

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